2025年3月30日 · TSPAN32 (Tetraspanin 32) is a Protein Coding gene. Diseases associated with TSPAN32 include Beckwith-Wiedemann Syndrome and Myeloma, Multiple. An important paralog of this gene is TSPAN2.

Tetraspanin-32 is a protein that in humans is encoded by the TSPAN32 gene. [5][6][7] This gene is described as a member of the tetraspanin superfamily whose expression is confined to hematopoietic tissues. [7]

2023年3月1日 · We found that TSPAN32 expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment inhibited the proliferation of Ph + cell lines. Tspan32 overexpression...

This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region.

我们在此报告， tspan32是费城 (ph + ) 白血病发病机制的关键节点因子。我们发现tspan32表达被 bcr-abl 抑制，并且伊马替尼治疗后异位 tspan32 表达抑制 ph +细胞系的增殖。 tspan32过表达可显着阻止 bcr-abl 在小鼠模型中诱导的白血病进展，并损害白血病干细胞 (lsc) 增殖。

The present study focuses on the characterization of TSPAN32 in T cell responses and provides the first proof of concept for a possible role of TSPAN32 in the immune dysregulation observed in MS, defining this molecule as a potential translational target for further studies.

2023年3月1日 · Tspan32 overexpression significantly prevented BCR-ABL induced leukemia progression in a murine model and impaired leukemia stem cell (LSC) proliferation. LSCs represent an obstacle for chronic myeloid leukemia (CML) elimination, which continually replenish leukemia cells and are associated with disease relapse.

2025年1月11日 · Tetraspanin 32 (TSPAN32), encoded by the TSPAN32 gene, located on human chromosome 11p15, is a bona fide member of the tetraspanin superfamily, although it differs structurally from typical tetraspanins by lacking the A/GFLGC motif and having a long C-terminal cytoplasmic domain.

2023年3月1 日，四川大学胡以国团队在Signal Transduction and Targeted Therapy在线发表题为“TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN”的研究论文，该研究表明TSPAN32通过稳定PTEN抑制慢性髓系白血病的发病和进展。

2019年9月4日 · Here, we show that TSPAN32 is expressed at higher levels in the lymphoid lineage as compared to myeloid cells. In vitro activation of T helper cells via anti-CD3/CD28 is associated with a significant downregulation of TSPAN32.