
Envelope stress responses defend against type six secretion …
2020年2月24日 · We report that TseH is a PAAR-dependent chaperone-independent effector highly toxic to Aeromonas and Edwardsiella species. We determine that E. coli is protected against TseH activity by two...
霍乱弧菌Ⅵ型分泌系统的效应蛋白对细菌细胞壁的降解机制
近年来,国内外对Ⅵ型分泌系统 (Type Ⅵ Secretion System,T6SS)的研究发现,T6SS可以跨过细胞壁将其Hcp (Haemolysin Co-Regulated Protein)内管、由VgrG (Valine-Glycine Repeat Protein G)和PAAR (Proline-Alanine-Alanine-Arginine)蛋白组成的尖端复合物以及毒性效应蛋白注射到临近的细胞中 [11 - 15]。 因此,T6SS作为一种细菌武器,能够穿透受体细菌的细胞膜和细胞壁将毒性效应蛋白注射到相邻的细胞中 [12 - 13, 16]。
Traumatic spinal epidural hematoma of a 10-month-old male: a
Traumatic spinal epidural hematoma (TSEH) is rare in children. Only three cases of TSEH were documented in the pediatric literature. This clinical note presents an infant with TSEH but no risk factors. Without magnetic resonance imaging examination, children with TSEH and minor symptoms may be misse …
Abiotic factors modulate interspecies competition mediated by …
2022年3月30日 · We found that V. cholerae could employ its cell-wall-targeting effector TseH to outcompete the otherwise resistant Escherichia coli and the V. cholerae immunity deletion mutant ∆tsiH when Mg2 ...
Yuan T. Lee - Wikipedia
Yuan Tseh Lee (Chinese: 李遠哲; pinyin: Lǐ Yuǎnzhé; Wade–Giles: Li³ Yüan³-che²; Pe̍h-ōe-jī: Lí Oán-tiat; born 19 November 1936) is a Taiwanese chemist who was awarded the Nobel Prize in Chemistry in 1986 with John C. Polanyi and Dudley R. Herschbach for "contributions to the dynamics of chemical elementary processes".
Porphyrin-based donor with asymmetric ending groups enables …
2023年8月1日 · ZnP-TSEH and Por-DPP-TR are porphyrin-based small molecules, which may indicate the excellent miscibility, and the phase separation as well as molecular stacking in ternary active layers are well adjusted as expected. The ternary device finally obtained a PCE of 16.31%. As far as we know, 16.31% ranks as one of the highest PCEs for ASM OSCs.
唐本钟院士团队Angew:分子内静电锁策略赋能高亮度近红外二区 …
2024年5月17日 · 基于tseh的纳米荧光染料,展示了比teh更高的近红外二区荧光亮度。 应用在肿瘤成像中,信噪比提高了2.2倍,有利于准确定位微小肿瘤并引导相关组织的切除。
课题组NIR-II-AIE分子合作成果发表在著名期刊Angew. Chem.
在这项研究中,我们报道了一种增强NIR-II聚集诱导发光(AIE)荧光体亮度的新策略,即通过分子内静电锁定。 通过在TSEH分子的噻吩桥的侧链中引入硫原子,可以通过硫和氮原子之间的分子内相互作用来锁定共轭骨架的分子运动。 这导致了TSEH在溶液和聚集态下NIR-II荧光发射的增强。 值得注意的是,TSEH的包埋纳米颗粒(NPs)显示出增强的亮度,比具有烷基侧链的TEH NPs高出2.6倍。 体内实验显示了TSEH NPs在血管和肿瘤成像中具有高信号与背景比和对微小肿瘤 …
Effective Steroid Treatment in Traumatic Cervical Spinal Epidural ...
Background: Traumatic spinal epidural hematoma (TSEH) is a rare neurosurgical condition that according to conventional treatment requires prompt surgical decompression. Recent reports, however, suggest that conservative management within the acute phase after trauma also can lead to similar long-term functional outcomes without the need for ...
Secretome analysis of Vibrio cholerae type VI secretion system ... - PubMed
2015年3月10日 · Additionally, this approach led to the identification of a new secreted protein encoded by VCA0285 (TseH) that carries a predicted hydrolase domain. We confirmed that TseH is toxic when expressed in the periplasm of Escherichia coli and V. cholerae cells.