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Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that affect humans and animals. The hallmark lesion of TSEs is spongiform changes in the brains of affected subjects.

Unique and customized automated phenotyping solution for mice or rats. Automated devices designed for forced exercise experiments, motor coordination and fatigue testing in rats and mice. Automated wheels for voluntary or active exercise tests in mice or rats, including workload module for resistance running.

2023年1月1日 · Transgenic mice have been at the forefront of research into the transmissible spongiform encephalopathies (TSE) (or prion diseases) since 1989 when the first transgenic mice were produced which overexpressed the hamster prion protein (PrP) via insertion of the hamster gene (Prnp) into the murine genome (Scott et al. 1989). Since then ...

However, after experimental transmission of a TSE to wild type or transgenic rodents a single or multiple phenotypes may emerge in a single mouse line, leading to the laboratory definition of a strain. According to this definition, classical scrapie includes several strains as various distinct phenotypes can be identified in mice 33 – 35).

It has been known for many years that transmissible spongiform encephalopathy (TSE) agents exhibit strain variation [1], a phenomenon that has been studied most extensively in experimental mouse models. Numerous distinct TSE strains have been isolated in mice from a...

Aim: We investigated the potential of PrP(Sc) immunohistochemistry and triplex Western blotting as possible alternative methods to differentiate between TSE strains. Methods: TSE reference strains ME7, 87A/87V, 22A/22C, 79A/79V and 301C/301V were intracerebrally inoculated in RIII or VM inbred mice that differ in their PrP genotype ...

2014年9月9日 · TSE reference strains ME7, 87A/87V, 22A/22C, 79A/79V and 301C/301V were intracerebrally inoculated in RIII or VM inbred mice that differ in their PrP genotype. Immunohistochemical PrP Sc profiles were drawn up by scanning light microscopy both on coronal and sagittal sections.

2003年6月1日 · Studies in mice have revealed considerable strain variation in the agents causing transmissible spongiform encephalopathies (TSEs). TSE strains interact with genetic factors in the host (in particular PrP genotype) to influence characteristics of the disease such as incubation period and neuropathology.