Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene. [5] The product of this gene belongs to the family of transient receptor potential (TRP) channels. [6] .

2023年2月23日 · TRPM3 -related neurodevelopmental disorder (TRPM3 -NDD) is characterized by congenital hypotonia, developmental delay, intellectual disability, seizures, and ophthalmologic and musculoskeletal manifestations.

2023年10月18日 · TRPM1 and TRPM3 are channels permeable to Ca 2+ and Zn 2+ regulated by neuroactive steroids that have crucial roles in ON-bipolar neurons of the retina, dorsal root ganglia neurons and other...

2024年12月25日 · TRPM3 (Transient Receptor Potential Cation Channel Subfamily M Member 3) is a Protein Coding gene. Diseases associated with TRPM3 include Cataract 50 With Or Without Glaucoma and Neurodevelopmental Disorder With Hypotonia, Dysmorphic Facies, And Skeletal Anomalies, With Or Without Seizures.

2021年2月26日 · However, recent research identifies TRPM3 as an emerging new player in the brain. In this review, we summarize the available data regarding the roles of TRPM3 in the brain, and correlate these data with the neuropathological processes in which this …

2025年2月28日 · The TRPM3 Foundation focuses on building community among patients and their families, caregivers, and healthcare providers, as well as funding of innovative research to accelerate treatment options and ultimately find a cure.

TRPM3 is dynamically regulated by plasma membrane PI (4,5)P 2 and related PIPs. The transient receptor potential (TRP) channel TRPM3 is a calcium-permeable cation channel activated by heat and by the neurosteroid pregnenolone sulfate (PregS).

2025年1月14日 · Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca 2+ -permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a...

2017年10月1日 · TRPM3 channels have a structure typical of all TRP channels with six transmembrane domains and a pore domain that is located between the fifth and sixth transmembrane domain (Fig. 1). TRPM3 channels have exceptionally long N-terminal and C-terminal domains that are both located in the cytosol.

2025年2月8日 · Pregnenolone sulfate is a powerful activator of TRPM3-mediated gene transcription, while transcription is completely inhibited by mefenamic acid in cells expressing activated TRPM3 channels.