Tryptophan metabolism: Mechanism-oriented therapy for …
This paper summarizes the factors regulating TRP metabolism (inflammation and stress, exercise, vitamins, minerals, diet and gut microbes, glucocorticoids, and aging) and the downstream (regulation of glutamate, immunity, Gpr35, nAChR, AhR, DA) role of TRP metabolism, and intends to provide a systematic introduction to its multi-linked regulation.
Kynurenines: Tryptophan’s metabolites in exercise ... - Science
2017年7月28日 · Here, we discuss peripheral mechanisms of tryptophan-kynurenine metabolism and their effects on inflammatory, metabolic, oncologic, and psychiatric disorders. Tryptophan (Trp) is an essential amino acid critical for protein synthesis, but it also serves as substrate for the generation of several bioactive compounds with important physiological ...
Gut Microbiota Regulation of Tryptophan Metabolism in Health …
2018年6月13日 · In the gut, the three major Trp metabolism pathways leading to serotonin (5-hydroxytryptamine), kynurenine (Kyn), and indole derivatives are under the direct or indirect control of the microbiota. In this review, we gather the most recent advances concerning the central role of Trp metabolism in microbiota-host crosstalk in health and disease.
Tryptophan metabolism in health and disease - Cell Press
2023年6月22日 · Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function.
Tryptophan metabolism in health and disease - ScienceDirect
2023年8月8日 · Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function.
Tryptophan Biochemistry: Structural, Nutritional, Metabolic, and ...
In substance, beside protein turn-over, Trp metabolism can be divided into two main branches: one, limited to approximately the 3–10% of these Trp biotransformations, which keeps the indole ring intact while producing chemical messengers as the indoleamines 5-HT, NAS, and MLT and the trace amine tryptamine and derivatives and the other, the ...
Dietary fibre directs microbial tryptophan metabolism via …
2024年6月25日 · Tryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites implicated in both beneficial and adverse host effects. How gut microbial tryptophan metabolism is...
Immune regulation through tryptophan metabolism
2023年7月3日 · The dietary essential amino acid tryptophan is converted by cellular metabolism into breakdown products that play regulatory roles in health and disease, some involving their effects on a gene ...
Diet-microbiome interactions promote enteric nervous system …
2024年8月29日 · With emerging evidence demonstrating SCI-induced alterations to gut microbiome composition, we hypothesized that microbiome modulation contributes to post-injury enteric recovery. Here, we show...
Effects of 3-week Tributyrin Supplementation on the Gut Microbiome…
Explore the intestinal microbial implications of 3-weeks tributyrin supplementation in healthy adults. Butyrate is a short chain fatty acid synthesized via the fermentation of non-digestible …