We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8 + Tregs by focusing on the characterization of …

两项研究深入探讨了调节性T细胞（Treg）在免疫调控中的关键作用。第一篇则聚焦于CD4+和CD8+ Treg细胞在自身免疫反应中的不同功能，发现CD4+Treg主要通过直接抑制B细胞调控自身抗体生成，而CD8+ Treg则主要控制T细胞耐受性，尤其在感染后自身免疫触发中起关键作用。

2022年8月30日 · Tregs是免疫抑制性T细胞，在预防自身免疫和病原体诱导的免疫病理学方面发挥关键作用，从而维持免疫稳态和自我耐受。 具有抑制活性的 CD8+ T 细胞在20世纪70年代就有人研究，然而，由于缺乏特异性标志物和基因表达调节分子，导致该研究方向一度被放弃。

2023年11月1日 · The diverse subsets of CD8 T cells, including Tc1 cells, Tc2 cells, Tc9 cells, Tc17 cells, Tc22 cells, Tfcs, and suppressive CD8 Tregs, have emerged as critical players in immune responses...

Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent autoimmune disorders. While the function and molecular regulation of Foxp3+CD4+ Tregs are well established, much of CD8+ Treg biology remains to be revealed. Here, we ...

In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8 + and CD4 + Tregs, and we will discuss the biology, development and induction of CD8 + Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future technically...

We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8 + Tregs by focusing on the characterization of individual CD8 + T-cell subsets with proposed regulatory capacity separately.

CD8 + Treg are loosely defined as a heterogenous population of CD8 + lymphocytes that can express several Treg associated surface markers and have immunosuppressive capacity, thus defining them as a Treg subset (131–133).

Recent studies of these lymphocytes, now popularly referred to as regulatory CD8+ T cells (CD8+ Tregs), have helped clarify their important role in the regulation of autoimmune disease. Here, we review progress related to the identification, phenotype and function of CD8+ Tregs.

2025年3月10日 · Tissue-resident CD4 + T helper cells play a supportive role in generating CD8 + T RM cells, potentially through the secretion of cytokines like IL-21, which can promote the survival and function of CD8 + T cells . Type 1 Treg cells have also been implicated in the generation of CD8 + T RM cells.