Single-cell RNA-seq reveals TOX as a key regulator of CD8
2019年6月17日 · We discovered a coexpression gene module containing Tox that exhibited higher transcriptional activity associated with more abundant active histone marks in progenitor-like cells than memory...
专家点评 | 3篇Nature1篇Nat Immuno揭示调控耗竭CD8+T细胞的 …
胸腺细胞选择相关HMG盒蛋白 （Thymocyte selection-associated HMG box protein, TOX）是细胞核DNA结合蛋白，也是HMG盒蛋白超家族（high-motility group box superfamily）成员之一，以结构依赖而非序列依赖的方式与核DNA结合 【4】。 已有文献可知，TOX对胸腺CD4+T细胞发育，NK细胞发育以及固有淋巴细胞发育都有重要作用 【5】。 但是其在慢性感染或肿瘤中耗竭 CD8+T细胞 中的作用还未知。 2019年6月17日，Nature以及Nature Immunology杂志同时发 …
3篇Nature，揭示TOX蛋白在调节免疫T细胞功能的关键作用_光谱网
2 天之前 · 2019年6月17日，威尔康奈尔大学医学研究生院Mary Philip及Andrea Schietinger共同通讯在Nature 在线发表题为“TOX is a critical regulator of tumour-specific T cell differentiation”的研究论文，该研究确定核因子，胸腺细胞选择相关的HMG盒蛋白，TOX，作为肿瘤特异性T细胞（TST）分化的 ...
Single-cell RNA-seq reveals TOX as a key regulator of CD8
Progenitor-like CD8 + T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint blockade.
TOX transcriptionally and epigenetically programs CD8 - Nature
2019年6月17日 · However, enforced TOX expression in NFAT2-cKO cells can restore early T ex differentiation, which demonstrates a key role for TOX as an inducer of T ex differentiation …
Continuous expression of TOX safeguards exhausted CD8 T cell
2025年3月7日 · Gene expression and epigenetic profiling revealed a critical role for TOX in maintaining chromatin accessibility and transcriptional patterns in committed T ex cells. Moreover, TOX removal endows established T ex cells with greater fate flexibility to differentiate into more functional effector-like T cells.
TOX for tired T cells - Nature Reviews Immunology
2019年6月26日 · Yao et al., Alfei et al. and Khan et al. identified a key role for TOX in promoting the survival of the progenitor-like TCF1 + CD8 + T cells that arise during chronic LCMV infection and can...
单细胞RNA测序揭示CD8+T细胞的长期存活—小柯机器人—科学网
2019年7月27日 · Moreover, thymocyte selection-associated high mobility group box protein TOX (TOX) promoted the persistence of antiviral CD8+ T cells and was required for the programming of progenitor-like CD8+ T ...
MAXPOWER 9-Piece Torx Key Set - amazon.com
2017年12月21日 · MAXPOWER 9-Piece Torx Key Set - Pro Grade Long Arm 6 point star tools T10, T15, T20, T25, T27, T30, T40, T45, T50
Torx Keys | McMaster-Carr
Choose from our selection of Torx keys, including rounded machine keys, machine keys, and more. Same and Next Day Delivery.