This document provides information about the composition, pharmacology, indications, dosage, and safety of TOTILAC® Infusion solution. It is a hypertonic lactate solution containing sodium lactate, potassium chloride, and calcium chloride. It can be used for fluid resuscitation after cardiac surgery.

Totilac (Hypertonic Lactate) is an innovator drug in its class and was granted an EU patent in 2006. Based on clinical studies, the Hyperosmolar lactate of Totilac is more effective than mannitol in achieving a prolonged decrease in intracranial pressure during an acute episode of intracranial hypertension.1 Totilac also offers two benefits in ...

The Totilac (Potassium Chloride) Extended Release Tablets USP, 20 mEq product is an immediately dispersing extended release oral dosage form of Totilac (Potassium Chloride) containing 1500 mg of microencapsulated Totilac (Potassium Chloride), USP equivalent to 20 mEq of potassium in a tablet.

TOTILAC® is a sterile non-pyrogenic solution containing hypertonic concentration of sodium lactate with physiological concentration of potassium chloride and calcium chloride in water for injection.

This was a prospective, randomized, single blind study aiming to evaluate the efficacy and safety of a scientifically formulated and patented hyperosmolar sodium-lactate infusion (Totilac ®, manufactured by PT Finusolprima Farma International-Indonesia) in improving neurocognitive function post MTBI compared to commercially available ...

2018年1月19日 · Hyperosmolar therapy is a mainstay of treatment for cerebral edema, creating an osmolar gradient within the blood-brain barrier. Mannitol and hypertonic saline have unique mechanisms of action and adverse effects, but both are …

pressure. Hypertonic sodium lactate (Totilac®) contains lactate which is considered to provide energy supplementation for ischemic brain. The combination of hyperosmolar properties with lactate in Totilac® is expected to have a better effect on reducing intradural pressure. Objective: to compare the intradural pressure after Mannitol® and ...

Learn about Totilac by Delex Pharma a 250 mL premixed hypertonic lactate solution, recognized for effectively reducing intracranial pressure during acute hypertension episodes