2024年10月11日 · Metoprolol increases the risk of death and stroke after non-cardiac surgery. Metoprolol is a beta-blocker drug used to treat high blood pressure and is often prescribed to patients with a history of heart disease, blood vessel disease, stroke, or other health problems such as diabetes or impaired kidney function.

Metoprolol is a common medication used by the elderly because it is affordable and has proven to decrease mortality in cardiovascular disease. Multiple studies have reported central nervous system (CNS) side effects associated with use of ...

Cardiovascular events and infections are common in the acute phase after stroke. It has been suggested that these complications may be associated with excessive sympathetic activation due to the stroke, and that beta-adrenergic antagonists ...

2018年3月12日 · During the 12 months after undergoing noncardiac surgery, patients with or at risk for heart disease who were treated with the beta blocker metoprolol for 30 days were less likely than patients who received a placebo to have a heart attack, but more likely to die or have a stroke, according to research presented at the American College of ...

Routine use of preoperative metoprolol, but not atenolol, is associated with stroke after noncardiac surgery, even after adjusting for comorbidities. Intraoperative metoprolol but not esmolol or labetalol, is associated with increased risk of perioperative stroke.

High blood pressure may also increase the risk of heart attacks or strokes. These problems may be less likely to occur if blood pressure is controlled. Metoprolol is also used to treat severe chest pain (angina) and lowers the risk of repeated heart attacks. It is given to people who have already had a heart attack.

Treatment of high blood pressure remains a cornerstone in stroke prevention, and beta‐blockers have now been used to treat hypertension and prevent strokes for almost 5 decades. The first beta‐blocker to be used in clinical medicine, propranolol, was originally invented to provide relief for patients with angina pectoris.

2025年2月27日 · RCTs from both the pre-reperfusion era and in the early reperfusion era have shown that early initiation of beta-blocker therapy reduces the risk of reinfarction and ventricular arrhythmias among patients with STEMI. 1–3 The COMMIT (Clopidogrel and Metoprolol in Myocardial Infarction) trial included 45 852 patients (approximately 50% received ...

2008年5月12日 · Further, 41 metoprolol patients versus 19 placebo patients suffered a stroke, indicating that patients receiving metoprolol had more than double the risk of a stroke. Considering the heart...

Beta-blockers are drugs that reduce heart rate and blood pressure, and have other effects that might also reduce the risks of stroke and heart attack. Searching for studies up to May 2014, we found two high quality trials involving 2193 participants that tested beta-blockers after stroke in people with a recent stroke or TIA.