2025年3月30日 · TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Byssinosis and Ataxia-Telangiectasia. Among its …

TOPBP1 primarily regulates the DNA damage repair response through its ability to activate the damage response kinase, ataxia-telangiectasia mutated and RAD3-related (ATR). It also plays …

该基因编码与拓扑异构酶 II β 的 C 末端区域相互作用的结合蛋白。 这种相互作用表明这种蛋白质通过 DNA 链的瞬时断裂在拓扑异构酶 II β 的催化反应中起支持作用。 [RefSeq 提供，2008 …

Human TopBP1 contains nine BRCT domains and functions in DNA replication initiation, checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its …

Now, TopBP1, a critical regulator of DNA replication and cell cycle checkpoints, has joined this list of proteins (Frattini et al., 2021). For this study, the authors concentrated on the ability of …

2025年2月9日 · We propose TOPBP1 as a breast cancer susceptibility gene. TopBP1 is regulated by PML by association and stabilization of the protein in response to IR-induced DNA damage …

2016年2月1日 · We show that TOPBP1 acts in homologous recombination (HR) repair, impacts olaparib response, and exhibits aberrant patterns in subsets of human ovarian carcinomas. …

2023年12月14日 · To elucidate the molecular mechanism of DNA topoisomerase Ⅱ binding protein 1 (TopBP1) involved in DNA damage repair response this study found several potential …

2014年10月1日 · TopBP1 and homologues (TopBP1-family) are all ‘scaffold’ or ‘hub’ proteins that are able to make numerous protein–protein interactions through their constituent BRCT …

2022年7月11日 · TopBP1在调控细胞周期检验点控制、复制叉阻滞及DNA损伤修复过程中发挥重要作用。 TopBP1在乳腺癌等多种肿瘤细胞中高表达，其与肿瘤患者差的预后相关，其功能受 …