Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene. [5] [6] [7] [8] TOM20 is one of the receptor systems of the translocase of the outer membrane (TOM) complex in the outer mitochondrial membrane.

Dec 25, 2024 · TOMM20 (Translocase Of Outer Mitochondrial Membrane 20) is a Protein Coding gene. Diseases associated with TOMM20 include Parkinson Disease 25, Autosomal Recessive Early-Onset, With Impaired Intellectual Development and Parkinson Disease 2, Autosomal Recessive Juvenile .

TOMM20 protein is highly expressed in both anaplastic thyroid cancer and papillary thyroid cancer compared to non-cancerous thyroid tissue. Tom20 was ubiquitously distributed in the organ of Corti, allowing well-delineated visualization of inner and outer hair cells.

Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored.

TOMM20 is a member of the mitochondrial translocase of the outer membrane, which functions to shuttle mitochondrial-targeted proteins to the mitochondrial matrix (Omura, 1998) and has been implicated in pathophysiology of Parkinson's disease (Franco-Iborra et …

Jan 5, 2025 · Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma. Roche ME, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Dec 1. PMID 32920118, Free PMC Article.

Jan 5, 2025 · Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma. Roche ME, Lin Z, Whitaker-Menezes D, Zhan T, Szuhai K, Bovee JVMG, Abraham JA, Jiang W, Martinez-Outschoorn U, Basu-Mallick ARoche ME, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Dec 1.

Oct 1, 2021 · Here we investigated the association of the receptor Tom20 with the TOM complex. Tom20 was found in the TOM complex, but not in a smaller subcomplex. In addition, a subcomplex was found without Tom40 and Tom7 but with Tom20.

Aug 10, 2023 · When TOMM20 was depleted, PCa cells underwent EMT, acquired the characteristics of cancer stem-like cells, and developed resistance to AR antagonists. The stable depletion of TOMM20 promoted the transdifferentiation of PCa …

TOMM20 is a nuclear-encoded subunit of the mitochondrial translocation complex, which imports other nuclear-encoded proteins. TOMM20 is expressed on the outer mitochondrial membrane, and its globular cytosolic domain functions as a receptor that recognizes mitochondrial targeting signals on nuclear-encoded mitochondrial proteins (summary by ...