Tom22 is a multifunctional organizer of the mitochondrial
1999年9月30日 · Tom22 is a multifunctional protein that is required for the higher-level organization of the TOM machinery. In the absence of Tom22, the translocase dissociates into …
Molecular architecture of the active mitochondrial protein gate
2015年9月25日 · The Tom22 TM α helix, possibly bent at Pro 112, tethers two Tom40 molecules through the interactions of its N-terminal and C-terminal parts with conserved residues of …
A Biochemical and Structural Understanding of TOM Complex …
Despite the vast and complex interactome of Tom22, studies in specific tissue types reveal the specialized roles Tom22 can play in cells. For example, cardiac cells, which have a heavy …
Science | 殷平团队揭示线粒体外膜TOM转位酶复合体组装的分子机 …
TOM是由7个亚基组成的膜蛋白复合体，包括核心通道Tom40（β桶膜蛋白）和6个单次α螺旋跨膜蛋白：调控蛋白Tom5、Tom6和Tom7以及受体蛋白Tom20、Tom22和Tom70。TOM的组装 …
Mitochondrial protein translocation machinery: From TOM …
2022年5月1日 · In addition to being conserved across all eukaryotes, the TOM complex is the sole ATP-independent import machinery for nearly all of the ∼1000 to 1500 known …
Mitochondrial inner-membrane protease Yme1 degrades outer …
2018年1月2日 · In this study, we report the unexpected identification of MOM proteins whose degradation requires the Yme1 -Mgr1-Mgr3i -AAA protease complex in mitochondrial inner …
Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate ...
The mitochondrial protein entry gate, the TOM complex, undergoes a dynamic conversion between the fully assembled trimer and the dimer lacking Tom22. Mitochondrial porin, Por1, …
Impaired Mitochondrial Fusion and Oxidative Phosphorylation …
2019年5月19日 · The deletion of Tom22 resulted in reduced mitochondrial fusion and ATP production and increased apoptosis in HUVECs. The overexpression of Tom22 restored the …
Tom22 is a multifunctional organizer of the mitochondrial
1999年9月30日 · Tom22 is a multifunctional protein that is required for the higher-level organization of the TOM machinery. In the absence of Tom22, the translocase dissociates into …
Porin Associates with Tom22 to Regulate the ... - ScienceDirect
2019年3月7日 · Here, we found that the porin Por1 acts as a sink to bind newly imported Tom22. This Por1 association thereby modulates Tom22 integration into the TOM complex, …