2017年4月4日 · In this study, we discovered a novel function of tankyrase1 (TNKS1) which initiates telomere SSBR. Tankyrase1 belongs to the poly (ADP-ribose) polymerase (PARP) superfamily, which consists of 18 proteins with a C-terminal conserved catalytic domain similar to its founding member, PARP1 (31).

Tankyrase 1的主要结构可以分为四个区域，从N端到C端，分别是富含组氨酸/ 脯氨酸 /丝氨酸（HPS）的结构域、ankyrin（ANK）重复结构域、无菌α-motif（SAM）结构域和PARP 催化结构域 （图1）。 Tankyrases 2在结构上与 Tankyrases 1同源，在ANK、SAM和PARP结构域的序列相似度分别为83%、74%和94%，但缺乏HPS结构域。 HPS结构域的功能仍然未知，而其他三个结构域的作用已被确定。 图1. Tankyrases 1 和 2 的结构示意图。 ANK结构域由24个ANK重复组 …

This study aimed to investigate the roles of mandarin fish (Siniperca chuatsi) TNKS1-like (scTNKS1-like) in the Wnt/β-catenin signaling pathway and its impact on infectious spleen and kidney necrosis virus (ISKNV) infection.

2021年12月7日 · We report here that Tankyrase-1 (TNKS1) controls protein glycosylation by Poly-ADP-ribosylation (PARylation) of a Golgi structural protein, Golgin45, at the Golgi. TNKS1 is a...

We have demonstrated that TNKS1 is a positive regulator of the Wnt/β-catenin signaling pathway, silencing of TNKS1 inhibits the growth, reduces the invasion ability of U251 and U87 cells with increased apoptosis via suppression of Wnt/β-catenin signaling pathway. Therefore, TNKS1 may be a new target of gene therapy for astrocytoma.

通过TNKS1比色酶活性实验，WXL-8表现更有效的TNKS1抑制作用(IC 50 为9.1nmol·L-1)。WXL-8在HepG2、Huh7、Hep40细胞中抑制细胞增殖和集落形成，通过稳定Axin1和Axin2，降低β-catenin蛋白水平。

2019年12月11日 · In this study, we up- and down-regulated the expression of the TNKS1 gene in U251 and U87 glioblastoma cell lines to investigate its effects on the proliferation, cell cycle, invasion, and to reveal mechanisms and regulatory role …

2025年3月30日 · The Tankyrases (TNKS1/PARP5A and TNKS2/PARP5B) are poly (ADP-ribose) polymerases that catalyze the ADP-ribosylation of target proteins. TNKS' are involved in the regulation of Wnt/beta-catenin signaling and have been implicated in the pathology of various forms of cancer.

2019年12月11日 · This study is aimed to further elucidate the biological functions of TNKS1 as well as its relationship with the Wnt/β-catenin pathway. Methods: TNSK1 overexpression and knockdown vectors were constructed and transfected into glioblastoma cell lines U251 MG and U87, respectively.

Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process.