Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6] It is a member of the tumor necrosis factor superfamily, a family of transmembrane proteins that are cytokines, chemical messengers ...

2025年3月30日 · ( TNFA_HUMAN,P01375) Tocris Summary for TNF Gene. NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in the cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immunological response to infections. Gene Wiki entry for TNF Gene ...

肿瘤坏死因子（TNF）旧称肿瘤坏死因子-α（TNF-α） [1] 以区别肿瘤坏死因子-β，属肿瘤坏死因子超家族一员，是一种涉及到系统性炎症的细胞因子，同时也是属于引起 急相反应 （ 英语 ： Acute-phase protein ） 的众多细胞因子中的一员。 主要由巨噬细胞分泌，不过有一些其它类型的细胞也 …

tnfa与tnfr1的结合导致形成膜相关的tnfr1蛋白信号复合物i改变的nf-jb诱导的基因表达或复合物i的不稳定会使细胞内信号复合物iia和iib的组装以及凋亡和坏死性细胞死亡的激活。 4、tnf-α的下游信号传导途径. tnf-α可以激活不同的途径来诱导凋亡，细胞存活或炎症。

肿瘤坏死因子( tumor necrosis factor，TNF )是由巨噬细胞分泌的一种小分子蛋白，正常人血清为4.3±2.8 mg/L。TNF-α主要由单核—巨噬细胞分泌；TNF-β主要由活化的T淋巴细胞分泌。TNF在体内外均能刺激IL-1的产生…

人类tnf-α基因于1985年成功 克隆 ，定位于6p21.4，长约3.6 kbp，有4个外显子和3个内含子，与主要组织相容性复合体（mhc）基因紧密连锁位于hla-b 和 hla-c2 位点之间的 mhc3 类基因区内，由tnfa和tnfb组成，分别编码tnfα和tnfβ。 位于启动子区238位和308位存在单核苷酸多态性，被认为可调节tnf的转录水平，与 ...

Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds ...

2010年1月19日 · Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence ...

TNF-α即肿瘤坏死因子α，也被称作cachectin和TNFSF1A，是TNF超家族的配体。它是一种多效细胞分子，在炎症、细胞凋亡和免疫系统发育中起着核心作用。 TNF-α由巨噬细胞、单核细胞、中性粒细胞、CD4 +T细胞、NK细胞…

Tumour Necrosis Factor alpha (TNF alpha) is a homotrimer protein consisting of 157 amino acids, is a potent pro-inflammatory cytokine.TNF alpha binds to its receptors, mainly TNFR1 and TNFR2, and then transmits molecular signals for biological functions such as inflammation and cell death.TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis.