TMEM63A - Wikipedia
Transmembrane protein 63A is a protein that in humans is encoded by the TMEM63A gene. [5] [6] [7] The mature human protein is approximately 92.1 kilodaltons (kDa), with a relatively high …
TMEM63A Gene - GeneCards | CSCL1 Protein | CSCL1 Antibody
2024年12月25日 · TMEM63A (Transmembrane Protein 63A) is a Protein Coding gene. Diseases associated with TMEM63A include Leukodystrophy, Hypomyelinating, 19, Transient Infantile …
Drosophila TMEM63 and mouse TMEM63A are lysosomal
2024年2月22日 · Here we identify the Drosophila TMEM63 (Dm TMEM63) ion channel as an intrinsic mechanosensor of the lysosome, a major degradative organelle. Endogenous Dm …
A novel heterozygous TMEM63A variant in a familial case with …
2024年7月1日 · Heterozygous transmembrane protein 63A (TMEM63A) variants cause transient infantile hypomyelinating leukodystrophy-19, which features remarkable natural resolution of …
综述与专论: 机械敏感性离子通道TMEM63A在髓鞘形成障碍相关疾 …
2022年4月21日 · 跨膜蛋白63A（transmembrane protein 63，TMEM63A）是一种机械敏感性离子通道（mechanosensitive ion channel，MSC），在髓鞘形成过程中发挥重要作用 …
裴端卿团队破解机械敏感离子通道OSCA/TMEM63力感应和传递机制
2023年6月20日 · 其中人源 osca/tmem63a 基因在大脑中高度表达，显示出更高压力激活的迷你电导特性 9 。作者纯化了人源 osca/tmem63a 蛋白并解析了其高分辨冷冻电镜结构，意外发现 …
Cation Channel TMEM63A Autonomously Facilitates …
2025年2月21日 · Accurate timing of myelination is crucial for the proper functioning of the central nervous system. Here, we identified a de novo heterozygous mutation in TMEM63A …
Activation mechanisms of dimeric mechanosensitive …
2024年8月29日 · OSCA/TMEM63 channels, which have transporter-like architectures, are bona fide mechanosensitive (MS) ion channels that sense high-threshold mechanical forces in …
Mechanosensitive channels TMEM63A and TMEM63B mediate …
2024年12月21日 · Here, we show that loss of the mechanosensitive channels TMEM63A and TMEM63B (TMEM63A/B) resulted in atelectasis and respiratory failure in mice due to a deficit …
TMEM63A transmembrane protein 63A [ Homo sapiens (human) ]
Knockdown of transmembrane protein 63A (TMEM63A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1: PubMed