Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the Toll-interleukin-1 receptor (TIR)‍-domain-containing adaptor-inducing IFN-‍β (TRIF). However, the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear.

Poly (I:C)可被 TLR3识别，诱导 NF-kB 的活化和细胞因子的产生。 不论是天然还是合成型dsRNA皆能诱导I型干扰素（IFN）和其他细胞因子生成。 Poly (I:C)被Toll样受体3（TLR3）所识别。 一旦被识别，TLR3通过β干扰素TIR结构域衔接蛋白（TRIF，也称为TICAM-1）激活转录因子干扰素调控因子3（IRF3），引起I型IFNs（尤其是IFN-β）的生成。 第二条通路涉及到TNF受体相关因子6（TRAF6）或受体相互作用蛋白1（RIP1）的募集，随后激活转录因子NF-κB 和AP-1。 …

2021年8月15日 · Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the Toll-interleukin-1 receptor (TIR)‍-domain-containing adaptor-inducing IFN-‍β (TRIF). However, the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear.

TLR trigger the induction of type I IFN (IFN-alpha/beta), providing a crucial mechanism of anti-viral defense. Until recently, TLR were thought to induce type I IFN responses by activating two transcription factors which belong to the IFN-regulatory factor (IRF) family, IRF-3 and IRF-7.

2008年4月29日 · Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF).

2005年4月1日 · IFN-α enhanced TLR3 protein expression in both cell types resulting in activation of IFN-β, IL-28, and IL-29 gene expression in response to poly(I:C) stimulation. Our results suggest that in the studied epithelial and endothelial cells TLR3 is the main receptor that detects viral exogenous genetic material.

2009年12月18日 · In this study, we showed that TLR3 expression and IFN-β secretion were reduced significantly in MoDCs from patients with CHB or ACHBLF, and we demonstrated that impaired TLR3 signaling in DCs was associated with liver damage in ACHBLF.

2010年9月9日 · TLR3/TRIF-induced IFN-β gene expression is negatively regulated by Mal via PRDI-III. To investigate the ability of Mal to modulate IFN-β induction at the transcriptional level, we used the NF-κB, IFN-β, PRDIV and PRDI-III luciferase reporter gene constructs.

Toll 样受体 3 (TLR3) 是 TLR 家族的成员，介导 I 型干扰素 (IFN) 促炎细胞因子和趋化因子的转录诱导，从而共同建立抗病毒宿主反应。 研究表明，与其他 TLR 家族成员不同，TLR3 是唯一完全依赖于含有 Toll-interleukin-1 受体 (TIR) 结构域的适配器诱导 IFN-β (TRIF) 的 RNA 传感 ...

2019年12月31日 · The primary outcomes of TLR3 activation are cytokine production (specifically IFN-β) and dendritic cell (DC) maturation. As well as dsRNA, herpes simplex virus (HSV) is reported to activate...