TIRAP (TIR domain containing adaptor protein) is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like …

该基因编码的蛋白质是参与免疫系统 TLR4 信号通路的 TIR 衔接蛋白。 它激活 NF-kappa-B、MAPK1、MAPK3 和 JNK，然后导致细胞因子分泌和炎症反应。 该基因的选择性剪接会产生 …

2025年3月30日 · TIRAP (TIR Domain Containing Adaptor Protein) is a Protein Coding gene. Diseases associated with TIRAP include Bacteremia 1 and Malaria. Among its related …

Tirap （含有衔接蛋白的TIR结构域）是与收费类受体相关的衔接子分子。 先天免疫系统通过Toll样受体（TLR）识别微生物病原体，该病原体鉴定了与病原体相关的分子模式。

2001年9月1日 · We have identified and characterized a Toll–interleukin 1 receptor (TIR) domain–containing adapter protein (TIRAP) and have shown that it controls activation of …

2001年9月1日 · TIRAP mediates a transmembrane signal that results in the activation of downstream signal transduction events independently of MyD88. As suggested by its name, …

The Toll-interleukin-1 Receptor (TIR) domain-containing adaptor protein (TIRAP) represents a key intracellular signalling molecule regulating diverse immune responses. Its capacity to function …

2021年7月7日 · TIRAP, also known as MyD88-adaptor Like (MAL), is an adapter molecule associated with receptor-mediated activation of host immune signaling (1, 2). The innate …

While the crucial role of Myd88 is well described, the contribution of other adaptors in mediating TLR signaling and function has been underestimated. In this review, we highlight important …

2025年2月8日 · Study reports that, in response to natural activators of innate immunity, the sorting adaptor TIRAP regulates TLR signaling from the plasma membrane and endosomes. …