Trapped ion mobility spectrometry (TIMS) provides an additional dimension of separation, accelerating diverse research applications from 4D-Omics to MALDI Imaging. Powered by Parallel Accumulation Serial Fragmentation (PASEF®), Bruker’s timsTOF instruments offer next generation speed and sensitivity to identify and quantify challenging ...

Discover the power of timsTOF Ultra in the realm of translational patient treatment. With its exceptional capabilities, timsTOF Ultra enables the precise mapping of FFPE tissue proteins to specific cancer regions, even with limited sample quantities.

The timsTOF Pro 2 provides in-depth proteome coverage for everyday cell line proteome quantification experiments directly by database searching and matching between runs without the need for a spectral library.

Our data demonstrate the superior performance of timsTOF HT for identifying and quantifying differences between biologically diverse samples, allowing for improved disease biomarker discovery in large cohort studies.

Mar 16, 2021 · The Bruker timsTOF Pro is an instrument that couples trapped ion mobility spectrometry (TIMS) to high-resolution time-of-flight (TOF) mass spectrometry (MS). For proteomics, lipidomics, and metabolomics applications, the instrument is typically interfaced with a liquid chromatography (LC) system.

The timsTOF Pro 2, powered by the latest parallel accumulation serial fragmentation (PASEF ®) technology, paves the way for 4D-Multiomics applications. With its proven robustness, high sensitivity and fast MS/MS acquisition, timsTOF Pro 2 is the platform of choice for 4D-Proteomics.

timsTOF was engineered by Bruker experts as an open platform to accelerate the adoption of ion mobility mass spectrometry analysis across all applications. Providing consistently high ion mobility resolution, timsTOF unravels the complexity of samples and unlocks insights that remain hidden in standard mass spectrometry.

Mar 30, 2025 · timsTOF features adjustable ion mobility separation based on Trapped Ion Mobility Spectrometry (TIMS), so you can explore samples in various and meaningful ways.

launched the timsTOF Pro for high speed and deep shotgun proteomics. The instrument offers a unique separation technique, Trapped Ion Mobility Separation (TIMS), and a unique acquisition method, Parallel Accumulation Serial Fragmentation (PASEF). TIMS and PASEF are exclusive to the timsTOF Pro mass spec-trometer. The Evosep One is a

With high resolution ion mobility separation, timsTOF adds an orthogonal dimension that increases peak capacity beyond the resolving power achieved by chromatography and time-of-flight. Whereas unresolved precursor ions can yield inconclusive structural assignment, timsTOF enables more confident and specific identification.