2025年3月30日 · TIE1 (Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1) is a Protein Coding gene. Diseases associated with TIE1 include Lymphatic Malformation 11 and Angiosarcoma. Among its related pathways are GPCR Pathway and ERK Signaling.

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells [6] and platelets. [7] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 …

Tie1通过p38依赖性机制上调细胞粘附分子VCAM-1、E-selectin和ICAM-1。 Tie1的表达可增强单核细胞来源的免疫细胞粘附于内皮细胞。 Tie1具有促炎症性效果，在内皮的炎症性疾病中起重要作用。

Tie1 directly interacts with Tie2 to promote ANG-induced vascular responses under noninflammatory conditions, whereas in inflammation, Tie1 cleavage contributes to loss of ANG2 agonist activity and vascular stability; Ang,Tie1 and Tie2 play roles in vascular development and pathogenesis of vascular diseases.[review]

2016年9月1日 · Endothelial Tie1 was essential for the agonist activity of ANG1 and autocrine ANG2. Deletion of endothelial Tie1 in mice reduced Tie2 phosphorylation and downstream Akt activation, increased FOXO1 nuclear localization and transcriptional activation, and prevented ANG1- and ANG2-induced capillary-to-venous remodeling.

2010年3月12日 · We provide evidence for Tie1-Tie2 complex formation on the cell surface and identify molecular surface areas essential for receptor-receptor recognition. We further demonstrate that the Tie1-Tie2 interactions are dynamic, inhibitory, and differentially modulated by angiopoietin-1 and -2.

Endothelial Tie1 was essential for the agonist activity of ANG1 and autocrine ANG2. Deletion of endothelial Tie1 in mice reduced Tie2 phosphorylation and downstream Akt activation, increased FOXO1 nuclear localization and transcriptional activation, and prevented ANG1- and ANG2-induced capillary-to-venous remodeling.

The endothelial tyrosine kinase receptor Tie1 remains poorly characterized, largely owing to its orphan receptor status. Global Tie1 inactivation causes late embryonic lethality, thereby reflecting its importance during development. Tie1 also plays pivotal roles during pathologies such as atherosclerosis and tumorigenesis.

该基因编码酪氨酸蛋白激酶家族的一个成员。 编码的蛋白质通过内皮受体酪氨酸激酶 Tie2 抑制血管生成素 1 信号，从而在血管生成和血管稳定性中发挥关键作用。 编码蛋白的胞外域切割解除了对 Tie2 的抑制，并由包括血管内皮生长因子在内的多种因素介导。 已经观察到该基因编码多种亚型的可变剪接转录物变体。 [RefSeq 提供，2011 年 11 月] This gene encodes a member of the tyrosine protein kinase family.

2024年1月30日 · Tie1（tyrosine kinase with immunoglobulin-like and EGF-like domains 1），是一种由细胞膜上表达的受体酪氨酸激酶。 该蛋白在血管内皮细胞中高度表达，并参与调控血管发育和血管新生的过程。