Thyroid hormone resistance (also resistance to thyroid hormone (RTH), and sometimes Refetoff syndrome) describes a rare syndrome in which the thyroid hormone levels are elevated but the thyroid stimulating hormone (TSH) level is not suppressed, or not completely suppressed as would be expected.

2025年2月9日 · Thyroid hormone resistance gets a lot of attention from thyroid patients for one very important reason: Because it has the potential to explain why so many thyroid patients continue to feel poorly despite taking thyroid medication and despite having thyroid lab …

2022年11月17日 · Thyroid hormone resistance (THR) is a rare condition that causes impaired sensitivity to thyroid hormones, which are involved in postembryonic development and physiological homeostasis. THR is caused by mutations in the thyroid hormone receptor beta (TRβ) or alpha (TRα).

2017年9月15日 · Mutations in both these genes have given rise to Resistance to Thyroid Hormone (RTH) syndromes (RTHβ, RTHα) that can have variable phenotypes for mutations of the same receptor isoform as well as between the two receptor isoforms.

2022年2月12日 · There are three known types of thyroid resistance, based on whether the cells of the pituitary gland are involved along with all the other cells in the different organ systems of our bodies. Diffuse, or generalized, thyroid resistance has been studied the most.

Resistance to thyroid hormone (RTH) is a heritable defect in thyroid hormone sensitivity, usually caused by defects in one of the two the thyroid hormone receptors (TRs). It is characterized by tissue responsiveness to thyroid hormone that does …

2022年1月21日 · Basically, thyroid hormone resistance is when the body doesn’t respond to thyroid hormones. Thyroid hormones are being produced, but the body is “resistant” to that hormone. Also known as subclinical hypothyroidism or hypothyroidism type 2, you could refer to it as pre-hypothyroidism.

Resistance to thyroid hormone is a rare genetic condition where some body tissues do not respond normally to thyroid hormones produced by the thyroid gland. It may be associated with no symptoms or with features of both an overactive and underactive thyroid.

2021年3月30日 · Resistance to thyroid hormone (RTH) is a clinical syndrome defined by impaired sensitivity to thyroid hormone (TH) and its more common form is caused by mutations in the thyroid hormone receptor beta (THRB) gene, termed RTHβ. The characteristic biochemical profile is that of elevated serum TH levels in absence of thyrotropin suppression.

Resistance to thyroid hormone (RTH) is a rare autosomal dominant inherited syndrome of reduced end-organ responsiveness to thyroid hormone. Patients with RTH have elevated serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations and normal or slightly elevated serum thyroid stimulating hormone (TSH) level.