Thrombopoietin, the Primary Regulator of Platelet Production: …
Thrombopoietin, the primary regulator of blood platelet production, was postulated to exist in 1958, but was only proven to exist when the cDNA for the hormone was cloned in 1994. Since its initial cloning and characterization, the hormone has revealed many surprises.
The biology of thrombopoietin and thrombopoietin receptor agonists
Thrombopoietin (TPO) is the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production.
Thrombopoietin and hematopoietic stem cells - PMC
Thrombopoietin (TPO) is the cytokine that is chiefly responsible for megakaryocyte production but increasingly attention has turned to its role in maintaining hematopoietic stem cells (HSCs).
The structure, function, and clinical use of the thrombopoietin ...
2022年5月1日 · Thrombopoietin regulates platelet production through activation of the thrombopoietin receptor (TPO-R). TPO-R agonists (TPO-RAs) are available to treat thrombocytopenia in chronic immune thrombocytopenia (ITP), chronic liver disease (CLD) patients who are undergoing a procedure, severe aplastic anemia (SAA), and hepatitis C virus (HCV) …
Thrombopoietin - an overview | ScienceDirect Topics
Thrombopoietin (TPO) – also known as megakaryocyte growth and differention factor or megapoietin – is a new member of the four-helix bundle cytokine family that is able to stimulate increases in levels of platelets in normal animals.
Biology and physiology of thrombopoietin - UpToDate
2023年3月29日 · Thrombopoietin (TPO) is the physiologically relevant regulator of platelet production. Although the concept of a platelet growth factor analogous to erythropoietin had been proposed in the 1950s, it was not until 1994 that the existence of this hematopoietic growth factor was demonstrated and the protein purified [ 1-5 ].
Thrombopoietin: biology and clinical potentials - PubMed
Thrombopoietin (TPO) is the principal physiologic regulator of platelet production. In vitro, TPO induces the growth of colony-forming units-megakaryocyte (CFU-MK) and the generation of mature polyploid megakaryocytes, which subsequently form extended cytoplasmic processes, termed proplatelets.
Thrombopoietin - an overview | ScienceDirect Topics
Thrombopoietin is an endogenous colony-stimulating factor that increases the number of megakaryocyte colonies in bone marrow and also induces maturation of megakaryocytes (1). Recombinant thrombopoietin is indicated for correction of thrombocytopenia, induced by chemotherapy or radiotherapy (1).
Thrombopoietin: a tool for understanding thrombopoiesis
Thrombopoietin (TPO) is a 332-amino acid glycoprotein produced by the liver, kidney, marrow stroma and several other tissues.
Thrombopoietin and Platelet Production in Chronic Immune ...
Since 1968, a greater understanding of platelet biology and its regulation by thrombopoietin (TPO) have emerged. It is now recognized that ITP is a disorder of both reduced platelet production and increased platelet destruction.
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