
Thiolase - Wikipedia
Thiolases, also known as acetyl-coenzyme A acetyltransferases (ACAT), are enzymes which convert two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway.
硫解酶 - 百度百科
thiolase 定 义 催化脂肪酸β氧化反应中硫解作用的酶。在辅酶A存在下,将β酮酰基辅酶A硫解为乙酰辅酶A和酰基辅酶A,后者较原先的酰基辅酶A少两个碳原子。 应用学科 生物化学与分子生 …
Thiolase - an overview | ScienceDirect Topics
Thiolase is a conserved enzyme present in the three domains of life (Bacteria, Archaea and Eukarya). This ubiquitous enzyme catalyzes the reversible thiolytic cleavage of 3-ketoacyl …
Redox-switch regulatory mechanism of thiolase from - Nature
2015年9月22日 · Thiolase is the first enzyme catalysing the condensation of two acetyl-coenzyme A (CoA) molecules to form acetoacetyl-CoA in a dedicated pathway towards the biosynthesis …
Thiolase: A Versatile Biocatalyst Employing Coenzyme A–Thioester ...
Thiolases are CoA-dependent enzymes that catalyze the thiolytic cleavage of 3-ketoacyl-CoA, as well as its reverse reaction, which is the thioester-dependent Claisen condensation reaction. …
A polyketoacyl-CoA thiolase-dependent pathway for the ... - Nature
2020年6月22日 · Here we show that certain thiolases, which we term polyketoacyl-CoA thiolases (PKTs), catalyse polyketide backbone formation via iterative non-decarboxylative Claisen …
硫醇酶 - 华文百科
硫氨酶,也称为 乙酰辅酶A乙酰转移酶 ( ACAT )是酶,在 甲酸酯途径 中将两个单位的 乙酰辅酶A 转换为 乙酰乙酰基COA 。 硫氨酶是普遍存在的 酶,在许多重要的生化途径中具有关键作 …
3-酮脂酰辅酶A硫解酶家族的分子特征、调节与药物靶向治疗
3-酮脂酰辅酶 A 硫解酶( 3 -ketoacyl CoA thio⁃ lase, 3-KAT) 是一类在脂肪酸 β -氧化裂解反应中 扮演重要角色的酶,包括线粒体型和过氧化物酶体 ( peroxisome) 型,二者分别由 …
乙酰乙酰辅酶A - 维基百科,自由的百科全书
乙酰乙酰辅酶A (英語: Acetoacetyl CoA)是 甲羟戊酸途径 中合成 β-羟基-β-甲戊二酸单酰辅酶A (HMG-CoA)的前体,是胆固醇合成的必要物质,在 肝臟 中的 酮体 合成里也有一定作用。 …
Thiolase Enzyme: Structure, Function, and Regulation in Metabolism
2025年1月12日 · Explore the crucial role of thiolase enzymes in metabolism, focusing on their structure, function, and regulatory mechanisms. Thiolase enzymes are essential in cellular …