2007年1月29日 · THF-diols and LTX-diols block female sexual behavior and cyclicity and stimulate breast cancer cell proliferation. Interestingly, the THF-diols, but not the LTX-diols, …

Tetrahydrofuran-3,4-diol | C4H8O3 | CID 90803 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …

2008年6月18日 · THF-diols (9,12-oxy-10,13-dihydroxyoctadecanoic and 10,13-oxy-9,12-dihydroxyoctadecanoic acids) are endocrine disrupters in rats and mitogens in breast cancer …

2024年5月3日 · A computational study is reported here on the mechanism of tetrahydrofuran (THF)-diol formation from the Os (VI)-catalyzed oxidative cyclization of 5,6-dihydroxyalkene …

2008年6月18日 · THF-diols (9,12-oxy-10,13-dihydroxyoctadecanoic and 10,13-oxy-9,12-dihydroxyoctadecanoic acids) are endocrine disrupters in rats and mitogens in breast cancer …

2024年5月17日 · A computational study is reported here on the mechanism of tetrahydrofuran (THF)-diol formation from the Os­(VI)-catalyzed oxidative cyclization of 5,6-dihydroxyalkene …

2007年6月1日 · THF-diols, LTX-diols, and/or their metabolites likely act additively to disrupt endocrine function in male and female rats at concentrations (0.5-1 ppm) that are 200-fold …

2016年4月30日 · A tandem olefin metathesis/oxidative cyclization has been developed to synthesize 2,5-disubstituted tetrahydrofuran (THF) diols in a stereocontrolled fashion from …

Higher concentrations (1-2 ppm) of THF-diols were required to block male sexual behavior. Combination studies with subthreshold doses of 0.05 ppm THF-diols plus 0.05 ppm LTX-diols …

THF-diol stimulation of MCF-7 cell proliferation is mediated through effects on the expression of the PLA2, COX-2, LOX-5, and LOX-12 genes and/or their respective enzyme activities. The …