2023年5月1日 · Theophylline is a drug derived from methylxanthine (a purine derivative) and has smooth muscle relaxant, bronchial dilation, diuretic, cardiac and central nervous system (CNS) stimulant activities. It is naturally present in small amounts in tea and cocoa beans and was initially extracted and synthesized in 1895 and used as a diuretic.

Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.

Theophylline, also known as 1,3-dimethylxanthine, is a drug that inhibits phosphodiesterase and blocks adenosine receptors. [1] . It is used to treat chronic obstructive pulmonary disease (COPD) and asthma. [2] . Its pharmacology is similar to other methylxanthine drugs (e.g., theobromine and …

Theophylline has two distinct actions; smooth muscle relaxation (ie, bronchodilation) and suppression of the response of the airways to stimuli (ie, non-bronchodilator prophylactic effects).

Similarly to other methylxanthines, theophylline has a dual mechanism of action: (I) it is a non-selective competitive phosphodiesterase inhibitor, and it is also (II) a non-selective competitive adenosine receptor antagonist.

2013年2月26日 · Theophylline is still one of the most widely prescribed drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) worldwide, because it is inexpensive and widely available. Theophylline (dimethylxanthine) occurs naturally in tea and cocoa beans in …

In COPD, low-dose theophylline is the first drug to demonstrate clear anti-inflammatory effects, and thus it may even have a role in preventing progression of the disease. Furthermore, the reversal of the steroid resistance induced by oxidative stress suggests that theophylline may increase responsiveness to corticosteroids.

2025年2月4日 · Theophylline package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology.

2013年10月15日 · Theophylline (dimethylxanthine) has been used to treat airway diseases for more than 80 years. It was originally used as a bronchodilator, but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β2-agonists became more widely used.

Theophylline, a drug that has been used for several de cades, has several different actions at a cellular level, including inhibition of phosphodiesterase isoenzymes, an tagonism of adenosine, enhancement of catecholamine se cretion, and modulation of calcium fluxes.