T helper 2 cells in asthma - PMC - PubMed Central (PMC)
Harker and Lloyd review the multifaceted roles of Th2 cells in human asthma, highlighting their influence of tissue location and disease severity. They also explore how Th2 cells and their …
Understanding Asthma Phenotypes, Endotypes, and Mechanisms …
In this review, we will provide an overview of molecular endotypes, asthma phenotypes, and existing biomarkers, with a focus on Th2 (also referred to as type 2 or T2) and non-type 2 …
The basic immunology of asthma - PubMed
2021年3月18日 · In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …
Current Understanding of Asthma Pathogenesis and Biomarkers
2022年9月5日 · Aberrant T helper type 2 (Th2) inflammation is the most important pathological process for asthma, which is mediated by Th2 cytokines, such as interleukin (IL)-5, IL-4, and …
Th2 cytokines and asthma: an introduction - PMC
Th2 cytokines may play an important role in the pathophysiology of allergic diseases, including asthma. They may be useful therapeutic targets in the future management of allergic diseases, …
T helper 2 cells in asthma - PubMed
2023年6月5日 · This review provides an update of our current understanding of Th2 cells in human asthma, highlighting their many guises and functions in asthma, both pathogenic and …
Innate players in Th2 and non-Th2 asthma: emerging roles for the ...
2024年10月14日 · In this review, we summarize recent findings on the regulation of and complex interplay between epithelial cells and the "nonclassical" innate effector cells mast cells and …
Type 2 immunity in asthma - World Allergy Organization Journal
2018年6月26日 · In infection, Th2 immune response provides an effective protection against helminths. Th2-induced IgE antibody production, mucus secretion, and mast cell activation …
Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma
2022年7月28日 · The role of Th2 cells in stable asthma. Among the various subpopulations of CD4 + cells, Th2 cells are most closely associated with the development of asthma. The …
Targeting cell signaling in allergic asthma | Signal ... - Nature
2019年10月18日 · The Th2 immune response is a major contributor to the pathophysiology of asthma. Targeted therapy modulating cell signaling pathways can be a powerful strategy to …