2020年11月26日 · The behavior of ex-Th17 cells in EAE lesions in vivo resembles Th1 rather than Th17 cells, underlining that their change in cytokine production is associated with functional …

2020年11月26日 · We show that EAE courses are highly dependent on in vitro differentiation and transfer protocols. Moreover, using genetically encoded reporter mice (B6.IL17A-EGFP.acRFP …

In the MOG35-55 induced EAE model, autoreactive Th17 cells that accumulate in the central nervous system (CNS) acquire Th1 characteristics via a T-bet dependent mechanism. It …

研究发现以表达细胞因子 IL-17 (Interlukin-17)和转录因子 RORγT 为典型特征的 Th17细胞 促进组织炎症发生，并在宿主抵抗病原体及自身免疫疾病的发病中起到重要作用。 但后续的研究发 …

Recent data have established that IL-17-producing CD4+ T cells, driven by IL-23 and referred to as Th17 cells, play a pivotal role in the pathogenesis of EAE. A combination of TGF-beta and …

2016年3月21日 · Interleukin 1β (IL-1β) is critical for the in vivo survival, expansion and effector function of IL-17–producing helper T (T H 17) cells during autoimmune responses, including …

2016年5月18日 · Early studies established that interleukin (IL)-17-producing CD4 + Th17 cells are required to induce EAE, as mice lacking RORγt, the Th17-specifying transcription factor, or IL …

2018年2月1日 · IL-17-secreting γδ T cells kick start the inflammatory process in EAE. Pathogenic Th17 cells can revert to Th1-type cells in vivo in EAE. Experimental autoimmune …

2009年6月25日 · We show that NIK has a critical role in Th17 cell differentiation and EAE induction, although this MAP3K is dispensable for the differentiation of Th1, Th2, and iTreg …

2022年12月17日 · Here we show that choline acetyltransferase (ChAT), which synthesizes acetylcholine (ACh), is a critical driver of pathogenicity in EAE. Mice with ChAT-deficient Th17 …