The tetrathionate anion reacts with a sulfhydryl to create a somewhat stable active intermediate, a sulfenylthiosulfate (Figure 2.121). Upon attack of the nucleophilic thiolate anion on this activated species, the thiosulfate (S 2 O 3 = ) leaving group is removed and a disulfide linkage forms ( Pihl and Lange, 1962 ).

A final method of forming disulfide crosslinks between toxins and targeting molecules is the use of S-sulfonate formation using sodium sulfite (Na 2 SO 3) in the presence of sodium tetrathionate (Na 2 S 4 O 6). Tetrathionate reacts with sulfhydryls to form sulfenylthiosulfate intermediates (Section 1.1). These derivatives are reactive toward ...

Tetrathionate is reduced by the molybdopterin-containing tetrathionate reductase TtrABC; this enzyme is induced under hypoxia by FNR (Hensel, Hinsley, Nikolaus, Sawers, & Berks, 1999) and uses electrons derived from organic electron donors, including alternative donors such as ethanolamine (Thiennimitr et al., 2011).

Tetrathionate is a compound that exhibits a dual binding effect when it interacts with cyanide, leading to the formation of thiosulfate and thiocyanate. It has shown promising results as an antidote in animal models, but its effectiveness and safety in humans are still uncertain.

2022年12月15日 · Tetrathionate was then hydrolyzed by SoxB to create sulfate and release H +. The remaining sulfate was converted to stable S 8 via polysulfide formation. S globules are also oxidized to sulfite in the presence of SdoA/SdoB, which is then transformed into sulfate ( …

2023年3月1日 · Tetrathionate hydrolase is one of the key enzymes involved in the dissimilatory sulfur metabolism of A. ferrooxidans. We have identified the gene encoding the enzyme ( Af-tth ) and determined the biochemical properties of the gene product ( Af -Tth) ( 17 ), tertiary structure by X-ray crystal analysis, and the tetrathionate hydrolysis reaction ...

2022年12月1日 · The results for tetrathionate “in” and “out”, pentathionate and hexathionate are presented in terms of area of the peaks of the chromatograms while the concentrations for thiosulfate and sulfate were measured experimentally in the leached solutions, as detailed in 2.3.2 Sulfate concentrations, 2.3.3 Polythionates analyses.

1979年4月1日 · Tetrathionate, cystine and hexacyanoferrate(III) function in phosphate buffer of pH 7, but iron(III) does not require rigid control of pH, although the solution should be only feebly acidic. The reagents were used in excess and the thiosulphate or cysteine formed in the reaction of thiols with tetrathionate or cystine respectively was determined.

2007年10月15日 · Tetrathionate hydrolase (4THase) plays a significant role in tetrathionate oxidation and should catalyze the initial step in the oxidative dissimilation when sulfur-oxidizing bacteria are grown on tetrathionate. 4THase activity was detected in tetrathionate-grown Acidithiobacillus ferrooxidans ATCC 23270 cells but not in iron-grown cells.

2003年12月1日 · The rate law for the overall oxidation of tetrathionate to sulfate has been defined as fractional in order with respect to both Fe 3+ and initial tetrathionate concentration In oxic, low pH conditions between 0.5 and 5 mM Fe 3+ the rate law is: r = 10 −6.61 ± 0.3 [S 4 O 6 2−] 0.3 ± 0.08 [Fe 3+] 0.15 ± 0.09 where the rate of sulfate ...