2023年7月3日 · Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin...

2018年5月2日 · Thioredoxin-binding protein-2 (TBP-2) has an important role in the redox system, but it plays a different role in many different diseases (e.g., various cancers, diabetes mellitus (DM), cardiovascular disease, and cataracts) by influencing cell proliferation, differentiation, apoptosis, autophagy, a …

2010年11月23日 · In this study, we show that disruption of thioredoxin binding protein-2 (TBP-2, also called Txnip) in obese mice (ob/ob) dramatically improves hyperglycaemia and glucose intolerance, without...

2020年8月18日 · Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) revealed that an evolutionarily conserved reduction-oxidation (redox) signal complex plays an important role for pathoph …

随后，在其吡啶基上分别引入不同数目（一个或两个）的正电荷，合成了目标产物TBP-1、TBP-2（图2A）.两个分子在400-620 nm范围内具有广泛的吸收 货号 规格

2018年5月2日 · Thioredoxin-binding protein-2 (TBP-2) has an important role in the redox system, but it plays a different role in many different diseases (e.g., various cancers, diabetes mellitus (DM), cardiovascular disease, and cataracts) by influencing cell proliferation, differentiation, apoptosis, autophagy, and metabolism.

在这项研究中，我们表明在肥胖小鼠 (ob/ob) 中破坏硫氧还蛋白结合蛋白 2（TBP-2，也称为 Txnip）可显着改善高血糖和葡萄糖耐受不良，而不影响肥胖或脂肪细胞因子浓度。

TBP-2 overexpression significantly inhibited PPARalpha-mediated transcriptional activity induced by a specific PPARalpha ligand in vitro. These results suggest that TBP-2 is a key regulator of PPARalpha expression and signaling, and coordinated regulation of PPARalpha and insulin secretion by TBP-2 is crucial in the feeding-fasting nutritional ...

We identified thioredoxin binding protein (TBP)-2 as a protein that interacts with thioredoxin in the yeast-two hybrid assay. (1) TBP-2 is identical to vitamin D 3 upregulated protein (VDUP)-1 (2) and also is referred to as thioredoxin interacting protein (Txnip).

2011年12月1日 · TXNIP (thioredoxin interacting protein, also known as Vitamin D3 up-regulated protein 1, VDUP-1; thioredoxin binding protein 2, TBP-2), is a key modulator of the redox system. It binds to the active cysteine residue of thioredoxin (TRX) and inhibits its antioxidative function ( Kaimul et al., 2007 ).