2024年1月26日 · Tau低聚物（TauO）——神经毒性最强的Tau类型——已知会诱导衰老和SASP，从而促进神经病理学、炎症、氧化应激、突触功能障碍、神经元死亡和认知功能障碍。TauO、脑部炎症和衰老与TauO病进展和认知能力下降的异质性相关。

tau蛋白是阿尔茨海默症（AD）等一系列神经退行性疾病的重点研究对象。过度磷酸化导致tau蛋白从微管上脱离、聚集形成可溶的tau蛋白寡聚体（Tauo），进而在神经元内形成神经纤维缠结，这些缠结是AD标志性特征之一。

In the present study, we report that (1) TauO-associated astrocytes exhibit markers of senescence-associated cell-cycle arrest (p16 INK4A), senescence-associated DNA damage (γH2Ax foci), and SASP (HMGB1) in the brains of patients with AD and FTD; (2) direct exposure of TauO triggers cellular senescence in cultured astrocytes; (3) HMGB1 release ...

综上， 本文通过解析8种常见的tau蛋白病中tau蛋白细丝的结构，结合已报道的结构，提出了基于tau蛋白折叠的tau蛋白病的分类方式，并依此鉴定出了一种新的tau蛋白病。 虽然潜藏于tau蛋白病下的分子机制仍然未知，tau蛋白细丝的结构生物学研究将成为继临床表征和神经病理学检查之外的第三种认识tau蛋白病的方式。 这些结构信息对tau蛋白病的研究提供了新的思路，同时对构建更准确特异的疾病模型、设计更灵敏特异的用于诊断的探针具有指导意义。 Nature | 基于结构 …

2020年5月4日 · Using brain-derived tau oligomers (BDTOs) from AD, PSP, and DLB patients, we investigated neuronal internalization mechanisms of BDTOs, including the heparan sulfate proteoglycan (HSPG)-mediated...

2021年7月20日 · Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia (FTD). However, the underlying mechanism of TauO-induced aging-related neuroinflammation remains unclear. Here, we show t …

2023年10月9日 · HIGHLIGHTS: Senescence, oligomeric Tau (TauO), and brain inflammation accelerate the aging process and promote the progression of tauopathies, including Alzheimer's disease. We discuss their role in contributing to heterogeneity in tauopathy and cognitive decline.

Soluble tau oligomers (TauO) are the most neurotoxic tau species that propagate pathology and elicit cognitive deficits, but whether ubiquitination contributes to tau formation and spreading is not fully understood.

2023年10月9日 · Tau oligomers (TauO)—the most neurotoxic tau species—are known to induce senescence and the SASP, which subsequently promote neuropathology, inflammation, oxidative stress, synaptic dysfunction, neuronal death, and cognitive dysfunction.

Tau 寡聚物 (TauO) 是最具神经毒性的 tau 物种，已知会诱导衰老和 SASP，从而促进神经病理学、炎症、氧化应激、突触功能障碍、神经元死亡和认知功能障碍。