2020年1月6日 · Targeted temperature management (TTM) is a complex intervention used with the aim of minimizing post-anoxic injury and improving neurological outcome after cardiac arrest. There is large variability in the devices used to achieve cooling and in protocols (e.g., for induction, target temperature, maintenance, rewarming, sedation, management of post-TTM …

2022年11月24日 · Most of the patients who die after cardiac arrest do so because of hypoxic-ischemic brain injury (HIBI). Experimental evidence shows that temperature control targeted at hypothermia mitigates HIBI. In 2002, one randomized trial and one quasi-randomized trial showed that temperature control targeted at 32–34 °C improved neurological outcome and mortality in …

2022年3月12日 · Background Temperature control with target temperature management (TTM) after cardiac arrest has been endorsed by expert societies and adopted in international clinical practice guidelines but recent evidence challenges the use of hypothermic TTM. Methods Systematic review and Bayesian meta-analysis of clinical trials on adult survivors from cardiac …

2024年5月20日 · Aims and scope The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admission to the intensive care unit for intracranial pressure (ICP) management. Methods A group of 18 …

2015年12月1日 · Targeted temperature management is thought to suppress many of the chemical reactions associated with reperfusion injury. These reactions, as mentioned previously, are associated with hyperthermia and include free radical production, excitatory amino acid release, and calcium shifts, which can in turn lead to mitochondrial damage and apoptosis.

2025年1月6日 · Targeted temperature management (TTM) is a standard treatment for post-cardiac arrest patients to mitigate the effects of reperfusion injury and improving neurological outcomes [6,7,8]. Current international cardiopulmonary resuscitation (CPR) guidelines do not recommend a specific target temperature for comatose patients after return of ...

2021年8月4日 · The use of targeted temperature management (TTM) has been recommended for two decades in the management of patients after cardiac arrest; however, the quality of evidence behind this recommendation is moderate to low and refers only to out-of-hospital cardiac arrest (OHCA) [1,2,3,4].

2024年1月9日 · Over the years, there's been kind of a "shift in paradigm," Rittenberger said, from therapeutic hypothermia to targeted temperature management and finally to temperature control, based on results ...

2012年6月7日 · Knowing the medical literature and knowing the issue of potentially life-threatening side effects and complications incurred by this invasive therapeutic manoeuvre, it is the foremost aim of this symposium and this supplementary issue of Critical Care to discuss all these aspects of targeted temperature management in emergency, critical care ...

2019年8月23日 · Background Although targeted temperature management (TTM) is recommended in comatose survivors after cardiac arrest (CA), the optimal method to deliver TTM remains unknown. We performed a meta-analysis to evaluate the effects of different TTM methods on survival and neurological outcome after adult CA. Methods We searched on the …