2025年3月30日 · TUBA1A (Tubulin Alpha 1a) is a Protein Coding gene. Diseases associated with TUBA1A include Lissencephaly 3 and Lissencephaly Due To Tuba1a Mutation. Among its …

Tubulin alpha-1A chain is a type of alpha-tubulin involved in the formation of microtubules, which are structural proteins that play a role in the cytoskeletal structure. Microtubules are composed …

The most common tubulin gene mutated is the α-tubulin gene TUBA1A, which is the most prevalent α-tubulin gene expressed in post-mitotic neurons. The normal role of TUBA1A …

The TUBA1A gene provides instructions for making a protein called alpha-tubulin (α-tubulin). This protein is part of the tubulin family of proteins that form and organize structures called …

TUBA1A is a gene that encodes a protein involved in the assembly of microtubules, and mutations of this gene can cause a particularly serious form of lissencephaly. You might find …

2025年2月20日 · Tandem affinity purification and mass spectrometry analysis identify subunit alpha 1a of tubulin (TUBA1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 …

该基因是染色体 12q 上簇中的三个 α-微管蛋白基因之一。 该基因的突变导致 3 型无脑回畸形 (LIS3) - 一种以小头畸形、智力障碍和由神经元迁移缺陷引起的早发性癫痫为特征的神经系统疾 …

tuba1a是一种重要的细胞骨架蛋白，属于微管蛋白家族，主要作为微管的组成部分，与β-微管蛋白（tubb）结合形成微管的二聚体。 其作用机制涉及在细胞分裂、物质运输和细胞形态维持等 …

2022年1月11日 · TUBA1A tubulinopathy is a relevant cause of congenital brain malformations as well as early-onset and intractable epilepsy with semiologic diversity. We here assess a …

Here, we test mutant tubulin levels and assembly activity and analyze the impact of TUBA1A reduction on growth cone composition, neurite extension, and commissural axon architecture …