2022年6月1日 · Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and innate...

Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that has emerged as a critical player in the development and progression of allergy and asthma. It is primarily produced by epithelial cells and functions as a potent immune system activator.

TSLP is expressed primarily by epithelial cells at barrier surfaces such as the skin, gut and lung in response to danger signals. Since it was cloned in 1994, there has been accumulating evidence that TSLP is crucial for the maturation of antigen presenting cells and hematopoietic cells.

Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and non-hematopoietic cell lineages, including dendritic cells (DCs), basophils, ...

2019年11月19日 · TSLP (thymic stromal lymphopoietin) is a member of the four-helix-bundle cytokine family and is a distant paralog of the cytokine IL-7 1. As its full name suggests, TSLP was first identified in...

Introduction: Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a central regulator of the immune response to inhaled environmental insults such as allergens, viruses and pollutants, initiating a cascade of downstream inflammation.

2025年2月8日 · TSLP is highly expressed in the skin of diffuse cutaneous systemic sclerosis patients and interacts in a complex manner with 2 other profibrotic cytokines, TGFbeta and IL-13. TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function.

2025年3月30日 · TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include Cryoglobulinemic Vasculitis and Allergic Asthma . Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System .

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine expressed in skin, gut, lungs, and thymus. TSLP signals via a TSLP receptor (TSLPR), a heterodimer of the IL-7 receptor alpha chain and the TSLPR chain.

2023年8月12日 · Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that has emerged as a critical player in the development and progression of allergy and asthma. It is primarily produced by epithelial cells and functions as a potent immune system activator.