一文搞定|活化的T细胞核内因子 (NFAT)的结构及其功能 - 知乎
研究发现，长期注射锂的小鼠脑部GSK-3活性被抑制，神经元细胞发生NFAT3/4的核转位，从而诱导死亡配体（Fas Ligand，FasL）表达水平的上升，激活FasL/Fas凋亡通路，下游凋亡蛋白 …
Development and Validation of Two Cell-Based Reporter-Gene
2025年2月24日 · In this paper, Gαs-cAMP-PKA and Gαq/11-PLC-Ca 2+, two signal transduction pathways that are intimately associated with TSH function, were successfully used to construct …
活化的T细胞核内因子（NFAT）的调节及其在神经系统中的功能
活化的T细胞核内因子（nuclear factor of activated T-cells, NFAT）作为细胞信号转导通路中的一类重要的转录因子参与细胞功能的调节. NFAT的活化主要是通过细胞内钙/钙调神经磷酸 …
Ca2+-binding protein expression in primary human thyrocytes☆
2013年12月1日 · Overexpression of S100A4 led to a reduced activation of NFAT by TSH. Using S100A4 E33Q, D63N, F72Q and Y75K mutants we found that the effects of S100A4 …
A Gq Biased Small Molecule Active at the TSH Receptor - PMC
By virtue of its structural property, the TSH receptor (TSHR) has a unique ability to engage different G proteins making it highly amenable to selective signaling. In this study, we describe …
NFAT proteins: key regulators of T-cell development and function
2005年6月1日 · NFAT proteins cooperate with lineage-specific transcription factors to determine pathways of T helper (T H)-cell differentiation into T H 1- or T H 2-cell populations. …
Signalling into the T-Cell Nucleus: NFAT Regulation
1998年10月1日 · The nuclear factor of activated T cells (NFAT) plays an important role in T-cell biology. Activation of T cells results in the rapid calcineurin-dependent translocation of NFAT …
The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a …
2019年11月7日 · (1) Background: Central congenital hypothyroidism (CCH) is a rare endocrine disorder that can be caused by mutations in the β-subunit of thyrotropin (TSHB). The TSHB …
NFAT proteins: key regulators of T-cell development and function
In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance. The functional versatility of …
一文搞定|活化的T细胞核内因子 (NFAT)的结构及其功能
2024年6月27日 · 活化的T细胞核内因子（Nuclear Factors of activated T cells， NFAT）是一类转录因子家族，最初是在活化的T细胞中作为一种能够结合在人白介素-2（Interleukin-2， IL-2） …