2021年1月14日 · 结节性硬化症蛋白复合体 （Tuberous Sclerosis Complex, 简称 TSC复合体）是mTORC1信号通路中重要的蛋白质复合体，其整合细胞外各种因素的刺激，负调控mTORC1复合体的活性，起到肿瘤抑制的作用。 TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。 其中TSC2包含一个GTP酶活化蛋白（GTPase activating protein，简称GAP）结构域，将GTP形式的Rheb水解为GDP形式的Rheb，导致Rheb失活，不能激活mTORC1的激酶活性，抑制细胞生 …

2025年3月30日 · TSC2 (TSC Complex Subunit 2) is a Protein Coding gene. Diseases associated with TSC2 include Lymphangioleiomyomatosis and Focal Cortical Dysplasia, Type Ii. Among its related pathways are Translation Insulin regulation of translation and MTOR signalling.

Tuberous sclerosis complex 2 (TSC2), also known as tuberin, is a protein that in humans is encoded by the TSC2 gene. Mutations in this gene lead to tuberous sclerosis. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases.

The TSC2 gene provides instructions for producing a protein called tuberin. Within cells, tuberin interacts with a protein called hamartin, which is produced from the TSC1 gene. These two proteins help control cell growth and division (proliferation) and cell size.

2016年5月26日 · Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple organ systems and is caused by loss-of-function mutations in one of two genes:...

这种 TSC 蛋白复合物负向调节哺乳动物雷帕霉素靶蛋白复合物 1 (mTORC1) 信号，后者是合成代谢细胞生长的主要调节因子。 该基因的突变与结节性硬化症和淋巴管平滑肌瘤病有关。 [RefSeq 提供，2022 年 5 月] This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth.

2002年8月12日 · Our data indicate a molecular mechanism for TSC2 in insulin signalling, tumour suppressor functions and in the inhibition of cell growth. TSC is a relatively common inheritable genetic disorder...

2021年1月14日 · TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。其中TSC2包含一个GTP酶活化蛋白（GTPaseactivatingprotein，简称GAP）结构域，将GTP形式的Rheb水解为GDP形式的Rheb，导致Rheb失活，不能激活mTORC1的激酶活性，抑制细胞生长。

The tumor-suppressor proteins TSC1 and TSC2 are associated with an autosomal dominant disorder known as tuberous sclerosis complex (TSC). TSC1 and TSC2 function as a heterodimer to inhibit cell growth and proliferation. Another protein, mTOR (mammalian target of rapamycin), is regarded as a central …

2021年1月14日 · 结节性硬化症蛋白复合体（Tuberous Sclerosis Complex, 简称TSC复合体）是mTORC1信号通路中重要的蛋白质复合体，其整合细胞外各种因素的刺激，负调控mTORC1复合体的活性，起到肿瘤抑制的作用。 TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。 其中TSC2包含一个GTP酶活化蛋白（GTPase activating protein，简称...