2023年1月12日 · Transient receptor potential vanillin 3 (TRPV3) is a member of the transient receptor potential (TRP) superfamily. As a Ca²⁺-permeable nonselective cation channel, TRPV3 can recognize thermal stimulation (31-39 °C), and it plays an important regulatory role in temperature perception, pain …

2025年3月30日 · TRPV3 (Transient Receptor Potential Cation Channel Subfamily V Member 3) is a Protein Coding gene. Diseases associated with TRPV3 include Olmsted Syndrome 1 and Palmoplantar Keratoderma, Nonepidermolytic, Focal 2 .

Transient receptor potential cation channel, subfamily V, member 3, also known as TRPV3, is a human gene encoding the protein of the same name. The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation .

TRPV3（transient receptor potential vanilloid-3）在皮肤、舌部及多种神经组织器官中表达。2002年，徐教授就发表了一作论文，他们克隆了人源TRPV3基因，首次揭示了TRPV3是一个温度敏感蛋白，在体温条件下通道开放，允许钙离子流入【4】。

TRPV3 is a central player in regulating physiological skin homeostasis. TRPV3 regulates proliferation, differentiation and apoptosis of human (as well as mouse) epidermal keratinocytes (Cals-Grierson & Ormerod, 2011; Miyamoto et al. 2009; Radtke et al. 2002; Cao et al. 2004). Specifically, its activation results in the inhibition of ...

2002年6月23日 · Here we have identified a member of the vanilloid channel family, human TRPV3 (hTRPV3) that is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain.

The transient receptor potential (TRP) channel TRPV3 plays a crucial role in skin physiology and pathophysiology. Mutations in TRPV3 are associated with various skin diseases, including Olmsted syndrome, atopic dermatitis and rosacea. Here we ...

2024年1月11日 · trpv3的发现及简介. trpv3是位于细胞膜上的一种对温度敏感(31℃~39℃)且受多种化学刺激的非选择性阳离子 钙渗透通道蛋白，它于2002年首次克隆，与其他trpv通道显示约30％~40％的序列同源性。

Transient receptor potential vanilloid subtype 3 (TRPV3) is an ion channel with a sensory function that is most abundantly expressed in keratinocytes and peripheral neurons. TRPV3 plays a role in Ca2+ homeostasis due to non-selective ionic ...

2022年10月30日 · 该研究探讨了Trpvicin抑制TRPV3的机制，为深入理解 TRPV3突变的致病机制及相关的药物开发提供了结构基础。 瞬时受体电位 （Transient Receptor Potential, TRP） 通道是一类可调控阳离子跨膜流动的非选择性离子通道。