TRPM8 - Wikipedia
TRPM8 is an androgen dependent Ca 2+ channel necessary for prostate cancer cells to survive and grow. Immunofluorescence showed expression of the TRPM8 protein in the ER and …
TRPM8 - 维基百科，自由的百科全书
瞬态感受器阳离子电压通道，子分类 M，成员 8（TRPM8），是一种存在于人类身上的蛋白质，由 TRPM8 基因 所编码，它又被称为 冷及薄荷醇感受器1（CMR1）[1]。 TRPM8是一种 离子通 …
温度敏感TRP通道：从2021年诺贝尔生理学或医学奖的温度感知机 …
2021年4月2日 · TRPM8激活可抑制Ang Ⅱ介导的RhoA相关蛋白激酶影响血管结构及功能。在肺动脉高压大鼠中，激活TRPM8可舒张肺动脉，与抑制SOCE有关 。TRPM8作用于GTPase …
Chapter 13 TRPM8: The Cold and Menthol Receptor - National …
This chapter focuses on TRPM8, describing what was known about cold signaling before the channel was cloned, how TRPM8 was identified as a cold sensor, and what advances have …
Science：解析出感知寒冷温度和薄荷醇的TRPM8蛋白结构
2017年12月28日 · 尽管最为人所知的是，TRPM8是感知适度寒冷温度（低于约25°C）和薄荷醇等冷感分子（cold-sensation molecule）的外周神经传感器，但是它也在许多其他正常组织中甚 …
TRPM channels in health and disease - Nature Reviews Nephrology
2023年10月18日 · TRPM2 and TRPM8 are non-selective cation channels. TRPM2 mediates ADP-ribose and reactive oxygen species signalling in neurons, immunocytes and kidney …
Structure of human TRPM8 channel - Communications Biology
2023年10月19日 · TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, …
TRPM8 channels: A review of distribution and clinical role
2020年9月5日 · The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca 2+ homeostasis. It has been proposed to be …
Regulation of TRPM8 channel activity - PMC
Transient Receptor Potential Melastatin 8 (TRPM8) is a Ca 2+ permeable non-selective cation channel directly activated by cold temperatures and chemical agonists such as menthol. It is a …
TRPM8 channels: A review of distribution and clinical role
2020年9月5日 · Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation …