
TRIM21 - Wikipedia
TRIM21 is an intracellular antibody effector in the intracellular antibody-mediated proteolysis pathway. It recognizes Fc domain [8] and binds to immunoglobulin G, immunoglobulin A [9] …
TRIM21 - 维基百科,自由的百科全书 - zh.wikipedia.org
TRIM21为一种 细胞内抗体介导蛋白水解 (英语:Intracellular antibody-mediated degradation) 途径的细胞内抗体效应子。 它会与标记感染细胞的无包膜 病毒体 的 抗体 上的 免疫球蛋白G …
TRIM21 Gene - GeneCards | RO52 Protein | RO52 Antibody
Mar 30, 2025 · TRIM21 (Tripartite Motif Containing 21) is a Protein Coding gene. Diseases associated with TRIM21 include Lupus Erythematosus and Heart Block, Congenital. Among its …
Cell重磅!发现基于TRIM21的分子胶和PROTAC降解剂,可选择性 …
为研究干扰素增强 ACE 抗癌活性的机制,研究人员进行了全基因组 CRISPR-cas9 筛选,发现, TRIM21是(S)-ACE-OH杀伤肿瘤细胞的关键因子。 在 TRIM21 敲除的 A549 细胞中,ACE …
1篇Cell+1篇Science:基于TRIM21 的“特洛伊木马疗法”,可靶向清 …
在这两篇论文中,研究者利用TRIM21创造了两种针对tau聚集物的新疗法。 第一种疗法是“RING-纳米抗体(RING-nanobody)”,它将结合tau蛋白的纳米抗体与 ...
TRIM21 regulates pyroptotic cell death by promoting …
Sep 11, 2021 · TRIM21-deficient cells displayed a reduced cell death in response to NLRP3 or NLRC4 inflammasome activation. Genetic ablation of TRIM21 in mice conferred protection …
TRIM21-dependent target protein ubiquitination mediates cell …
Feb 28, 2023 · Tripartite motif-containing protein 21 (TRIM21) is a cytosolic antibody receptor and E3 ubiquitin ligase that promotes destruction of a broad range of pathogens. TRIM21 also …
Science︱重磅!剑桥大学团队证明胞内抗体TRIM21介导小鼠模型 …
胞质Ab受体和E3 泛素连接酶 TRIM21 (The cytosolic Ab receptor and E3 ubiquitin ligase, T21)可与胞内Ab结合颗粒(Ab-bound particles)结合,并在 蛋白酶体 上产生强大的降解反 …
TRIM21胞内免疫功能与治疗应用 - 国际免疫学杂志
三基序蛋白21 (tripartite motif containing-21,TRIM21)含有多个结构域,从N端到C端,分别是具有E3泛素连接酶活性的RING结构域、B-box结构域、Coiled-coil结构域以及PRYSPRY结构域。
Frontiers | TRIM21—From Intracellular Immunity to Therapy
The use of genetic KO of TRIM21, both in vitro and in mice, together with specific KO of the interaction on the protein level using engineered antibody variants have solidified the role of …