Nat Commun：小胶质细胞中TREM2参与阿尔兹海默症调控新机制
2020年11月14日 · 在这些小胶质细胞相关的AD风险位点中，髓样细胞表达触发受体2（TREM2）基因上的变异对疾病风险影响最大，与单个APOE ε4等位基因产生的风险相似。 …
TREM2 — a key player in microglial biology and Alzheimer …
2018年9月28日 · In this Review, we focus on a receptor known as triggering receptor expressed on myeloid cells 2 (TREM2), which promotes the optimal microglial function required to …
Higher plasma soluble TREM2 correlates with reduced cerebral …
2025年4月1日 · Loss-of-function mutation of triggering receptor expressed on myeloid cell 2 (TREM2) is associated with increased risks for Alzheimer’s disease (AD). Recent animal …
TREM2 in the pathogenesis of AD: a lipid metabolism regulator …
2022年6月3日 · Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and …
New insights into the role of TREM2 in Alzheimer’s disease
2018年12月20日 · These findings advance our understanding of TREM2 involvement in the response of microglia to Aβ aggregation and its consequences and strongly encourage …
TREM2 risk variants and associated endophenotypes in …
2025年3月6日 · Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer’s disease (AD), and drugs targeting the TREM2 …
Enhancing TREM2 expression activates microglia and modestly …
2025年3月23日 · TREM2, a microglia-specific receptor, is strongly associated with Alzheimer’s disease (AD) risk, mediating microglial responses to amyloid pathology critical to AD …
Gene expression and functional deficits underlie TREM2-knockout ...
2020年10月23日 · By combining transcriptomic and functional analyses with a chimeric AD mouse model, we find that TREM2 deletion reduces microglial survival, impairs phagocytosis …
A systematic review of the role of TREM2 in Alzheimer’s disease
2025年3月25日 · Background::Given the established genetic linkage between triggering receptors expressed on myeloid cells 2 (TREM2) and Alzheimer’s disease (AD), an expanding research …
Roles of TREM2 in the Pathological Mechanism and the ... - PubMed
This article summarized the latest advances in TREM2 biology and its impact on the roles of microglia in AD development, with a particular emphasis on the structure, ligands, signal …