TREM2 is a member of the immunoglobulin superfamily. Endogenous ligands of this receptor are unknown but when triggered, it signals through the transmembrane adapter protein …

Feeding the small molecule agonist to cynomolgus macaques triggered a dramatic drop in levels of soluble TREM2 in their CSF over the first 24 hours, followed by a return to baseline levels …

TREM2 encodes Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that modulates microglial activity and survival. TREM2 variants cause Nasu-Hakola disease …

Jan 23, 2023 · As seen by SPECT imaging, much more ATV:TREM2 flooded the mouse brain (right) after intravenous injection than anti-TREM2 without the antibody transport vehicle (left). …

Feb 7, 2018 · TREM2 is associated with the risk of Alzheimer's disease in Spanish population. Neurobiol Aging. 2013 Jun;34(6):1711.e15-7. Epub 2013 Feb 5 PubMed. Finelli D, Rollinson …

Mar 13, 2018 · The TREM2 knockout microglia poorly phagocytosed beads in culture, while BAC-TREM2 mice ate voraciously, in agreement with previous studies suggesting that TREM2 …

Aug 31, 2017 · Thinking that limiting ectodomain shedding might improve TREM2 signaling (see image below), the three research groups set out to find the cleavage site. Snip Site. ADAM10, …

Jul 14, 2020 · Availability: TREM2 mice are available through Marco Colonna. Summary. This mouse model, referred to here as TREM2 CV, expresses the common variant of human …

Jul 29, 2021 · After TREM2 ASO treatment (bottom), plaques are sparse and microglia (green) more ramified, indicating a resting state. [Courtesy of Schoch et al., PNAS.] TREM2 …

Mar 17, 2022 · TREM2 is a cell surface receptor of the immunoglobulin superfamily that is expressed exclusively in the myeloid lineage cells, particularly microglia in the central nervous …