TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a mediator of the anti-apoptotic signals from TNF receptors.

TRAF proteins associate with, and mediate the signal transduction from members of the TNF Receptor Superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/ JNK and NF-kappaB.

肿瘤坏死因子受体相关因子 (tumor necrosis factor receptor-associated factors, TRAF)是一类重要的具有多功能的细胞内信号转导因子。 TRAF参与多种受体家族的信号转导，包括肿瘤坏死因子受体家族 (tumor necrosis factor receptor, TNFR)和Toll样-IL-1受体 (Toll-like receptors-interleukin-1 receptors,TLR-IL-1R)家族等，在固有免疫和获得性免疫中发挥重要作用。 目前研究表明，TRAFs不仅仅是一个接头分子，它还可能作为一个调节分子发挥作用。 下面就来跟大家分 …

2024年12月25日 · TRAF2 (TNF Receptor Associated Factor 2) is a Protein Coding gene. Diseases associated with TRAF2 include Myeloma, Multiple and Hematologic Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.

2023年4月20日 · TRAF2 depletion inhibited growth and survival of liver cancer cells both in vitro and in vivo by causing p62 accumulation, which is partially rescued by simultaneous p62 knockdown....

2015年7月22日 · TRADD ,RIP 和 TRAF2 ,参与凋亡和抗凋亡通路. 用,最终激活NF -κB 诱导基因表达和抗凋亡. 路,诱导细胞凋亡. 此外,可以依赖 TRAF2 寡聚抗. 碍激活凋亡通路 ( TRADD/ FADD/ caspase - 8) . 见, TRAF2 参与所有通路. 多数是用于调控而不是有活性的信号传导成分.

Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other signaling proteins, including plasma membrane receptors, kinases, phosphatases, other E3 ligases, and deubiquitinases.

人 TRAF 2 的单体 TRAF 结构域。 约有 150 个氨基酸的 TRAF 结构域可见于 肿瘤坏死因子 (TNF) 受体 相关 因子。 TRAF 蛋白似乎是一种相对最新进化的发育蛋白，因为只有一种 秀丽隐杆线虫 TRAF 蛋白、两种果蝇和六种哺乳动物 TRAF 蛋白。 除了在胞核中发现的 TRAF 4 之外，所有哺乳动物 TRAF 位于细胞浆。 通过其 TRAF 结构域与激活 TNF 受体、IL-1/Toll 受体之间的相互作用或通过 TRADD 等中间蛋白， TRAF 蛋白聚集到膜。 通过激活 NF- κB 和 AP-1 转录因子， …

traf2作为衔接蛋白和泛素e3连接酶，在介导tnfα-nfκb信号通路中发挥重要作用，并在多种人类癌症中表达失调，但traf2是否调节肝癌细胞的生长尚不清楚。

TRAF2 and TRAF5 therefore regulate diverse physiological roles, ranging from T and B cell signaling and inflammatory responses to organogenesis and cell survival. The major pathways mediated by TRAF2 and TRAF5 are the classical and alternative pathways of NF-κB activation, and MAPK and JNK activation.