6H or 9H has been used most often for TPT worldwide. Isoniazid is, however, increasingly being replaced by rifamycin regimens, which are becoming more affordable and feasible and with more evidence on their efficacy and safety in different populations.

A strong recommendation for TPT alternatives to 6 months of daily isoniazid monotherapy (6H), based on evidence of moderate to high certainty, has featured in previous WHO guidance (17,37,77). These consist of 3 months of weekly isoniazid plus rifapentine (3HP) and 3 months of daily isoniazid plus rifampicin (3HR).

2024年10月12日 · For those with latent genital TB, TPT is recommended using regimen for active TB treatment. For those with LTBI and reproductive system samples that are negative for TB nucleic acid testing, 6H regimen is recommended for TPT (2D).

Current recommendations for TPT in children with HIV of all ages include 3HR and isoniazid-based regimens; additional data are still required for 3HP in children under the age of two. As per NTEP India, the 6H regime has been adopted for prophylaxis in children below six years.

TPT treatment options recommended under NTEP include: 3-month weekly Isoniazid and Rifapentine (3HP) 6-months daily isoniazid (6H) Table 1: TPT Options for Target Population; Source: (Guidelines for Programmatic Management of Tuberculosis Preventive Treatment)

2024年12月25日 · 6H can reduce the incidence of ATB in minority areas with high burdens of TB and HIV/AIDS. Periodic counselling of patients on adherence and retraining of the TPT staff are essential. Health monitoring and education for specific populations improve TPT …

2024年9月1日 · 【推荐意见16】针对矽肺患者中的ltbi者，建议首选6h开展tpt(1d)。 【推荐意见17】针对长期口服糖皮质激素（ 泼尼松 等效剂量≥15 mg/d，持续4周以上）或使用其他免疫抑制剂的LTBI者，在临床综合评估的基础上，建议首选3H2P2方案进行TPT，存在合并用药禁忌者可 …

2021年8月16日 · Ada dua pilihan utama untuk TPT yaitu: paduan 6H (Isoniazid) dan 3HP (Isoniazid/Rifapentine). Paduan 6H adalah: paduan isoniazid (INH) yang diberikan selama 6 bulan dan dikonsumsi satu kali sehari. Paduan 3HP adalah: paduan TPT jangka pendek.

2022年7月9日 · 更短、更安全、更便宜的结核病预防性治疗方案（tpt）将有助于提高治疗接受率和有效性。 世界卫生组织制定了目标产品的简介，描述了新型TPT方案关键属性的最低要求和最佳目标。

Medication is given to people with latent TB infection (LTBI) (inactive TB) to prevent them from getting sick. The main TPT options are 3HP, 3RH and 6H (INH). 3HP is a combination of 2 drugs, isoniazid (H) and rifapentine (P) which are taken once …