TPH2 - Wikipedia
Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic neurons of the brain, with the …
色氨酸羟化酶 - 百度百科
Duke大学医学中心的分子生物学教授James B. Duke等又在动物试验中观察到，一种名为色氨酸羟化酶-2 (TPH2)的特殊蛋白会影响小白鼠脑组织中的 5-羟色胺 正常含量，而后者对于机体的精 …
TPH2 Gene - GeneCards | TPH2 Protein | TPH2 Antibody
Mar 30, 2025 · TPH2 (Tryptophan Hydroxylase 2) is a Protein Coding gene. Diseases associated with TPH2 include Major Depressive Disorder and Depressive Disorder. Among its related …
新型药物靶点——外周5-羟色胺 - 雪球
Jul 24, 2018 · TPH2主要表达于脑干中缝神经元和肠道肌肠层神经元，被认为是5-HT中枢神经递质池的来源；而大多数血液中的5-HTP是由胃肠道表达TPH 1的ECs合成的，储存在血栓性细胞 …
Advances in Tryptophan Hydroxylase-2 Gene Expression …
The pharmacological significance of TPH2 lies in that: 1) TPH2 is a promising target for the development of new therapeutic strategies in neuropsychiatric disorders; and 2) TPH2 gene …
Structural characterization of human tryptophan hydroxylase 2 …
Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in serotonin biosynthesis in the brain. Consequently, regulation of TPH2 is relevant for serotonin-related diseases, yet the …
Tryptophan hydroxylase 2 as a therapeutic target for ... - PubMed
Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 gene are …
色氨酸羟化酶 2（TPH2）基因 | MCE - MCE-生物活性分子大师
该基因编码依赖蝶呤的芳香酸羟化酶家族的一个成员。 编码的蛋白质催化血清素生物合成的第一步和限速步骤，血清素是一种重要的激素和神经递质。 该基因的突变可能与双相情感障碍和重 …
Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 …
Dec 12, 2006 · Tryptophan hydroxylase 2 (TPH2) is a recently discovered isoform of TPH that is specifically expressed in the brain, with particularly high expression in the serotonergic...
色氨酸羟化酶2作为精神疾病的治疗靶标：关注 ... - X-MOL
简介：色氨酸羟化酶2（TPH2）是大脑中5-羟色胺（5-HT）合成的关键，限速酶。 人类 Tph2 基因的某些多态性变体与精神疾病有关。 涵盖的领域：本综述着重于精神疾病模型中TPH2活性与 …
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