2023年7月27日 · Here, we discovered that the simultaneous mutations in TP53 and activation of c-MET occur in ~20% of human HCCs, and these patients show a poor prognosis. …

2007年4月2日 · Multiple genetic and epigenetic changes are involved in the molecular pathogenesis of HCC, for example, somatic mutations in the p53 tumor suppressor gene …

2025年1月29日 · Telomerase reverse transcriptase (TERT) promoter mutations (TERTpm) and cellular tumor antigen p53 mutations (TP53m) have been frequently documented in HCC, but …

为了系统地评估HCC中TP53错义突变对转录激活的潜在影响，该研究对结合TP53及赖氨酸H3K27ac的全基因组进行了数据分析，并对4种TP53突变体（L3环及非L3环各两个）进行 …

There is a strong association between TP53 mutations and hepatocellular carcinoma (HCC). According to the Catalog of Somatic Mutations in Cancer (COSMIC) database, 30% of all HCC …

Here we present a comprehensive review evaluating somatic mutations in TP53 and CTNNB1 genes in HBV- and HCV-related HCCs. Moreover, we report the mutational analysis of TP53 …

We investigated how TP53 mutation regulates the HCC immunophenotype and thus affects the prognosis of HCC. Methods: We investigated TP53 mutation status and RNA expression in …

2023年8月1日 · 在本研究中，研究人员通过流体动力学转染c-met癌基因和crispr-cas9介导的p53的ko，建立了小鼠hcc模型，可以有效地应用于研究tp53阴性hcc的体内进展。 为了进一步阐明 …

In this study, we found the TP53 mutation was positively correlated with senescence in HCC, and the differential expressed genes were primarily located in macrophages. Our results proved …

TP53 mutation is the most common mutation in hepatocellular carcinoma (HCC), and it affects the progression and prognosis of HCC. We investigated how TP53 mutation regulates the HCC …