Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage
2021年12月9日 · Another gene that often has abnormal expression in human cancers is TP53 which encodes the tumor suppresser protein p53 4. It has been demonstrated that both Plk1 …
TP53基因突变与药物（一） - 知乎专栏
tp53基因可以在多个肿瘤类型里发生，不同肿瘤类型中tp53基因的突变频率不同，最高的是子宫癌肉瘤，肺腺癌居然也达到了60%多。 TP53基因在约90%的小细胞肺癌（SCLC）和约50%的 …
Utilizing TP53 hotspot mutations as effective predictors of …
2025年1月27日 · Gemcitabine is a treatment option for patients with non-small cell lung cancer (NSCLC) who carry TP53 hotspot mutations. This potential effectiveness might arise from its …
Targeting mutant p53 for cancer therapy: direct and indirect strategies
2021年9月28日 · Due to the shortcomings in the G1 arrest of TP53-mutated malignancies, current studies focus on the suppression of G2 arrest. However, more studies should be conducted to …
Integrated Analysis of TP53 Gene and Pathway ... - ScienceDirect
2019年7月30日 · Roles for cell division, G2/M checkpoint control, E2F target genes, and documented repression by p53 are indicated by blue boxes. Significant upregulation in …
Hepatocellular cancer cell lines, Hep-3B and Hep-G2 display the ...
2022年9月1日 · Using 3- (4,5-dimethylthiazol-2-yl)-5- (3-carboxymethoxyphenyl)-2- (4-sulfophenyl)-2H-tetrazolium (MTS) assay, we investigated various and opposing effects in …
Tumor Suppressor p53: Biology, Signaling Pathways, and …
TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …
P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint
2020年4月21日 · We found that G2 DNA damage suppressed SENP3 phosphorylation at G2/M phases in p53-dependent manner. We further found that the suppression of SENP3 …
Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M ... - PubMed
2021年5月3日 · Overall, this work presents Aurora kinase inhibitors alone or in combination with WEE1 inhibitors as relevant mechanism driven therapies for TP53 mutant UCs. Context …
TP53 Regulates Transcription of Genes Involved in G2 Cell
2019年1月17日 · TP53 contributes to the establishment of G2 arrest by inducing transcription of GADD45A and SFN, and by inhibiting transcription of CDC25C. TP53 induces GADD45A …