细胞中抑制癌变的基因“tp53”会判断dna变异的程度，如果变异较小，这种基因就促使细胞自我修复，若dna变异较大，“tp53”就诱导细胞凋亡。 在人的基因里面，TP53是非常重要的抑癌基因， …

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in …

6 天之前 · p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage). …

2017年11月13日 · TP53基因，又称为p53基因，是因为编码一种分子量为53kDa的蛋白质而得名。 被作为著名的“抑癌基因”而被广泛研究。 简单来说，TP53基因编码的p53蛋白其中的重要作用 …

tp53基因可以在多个肿瘤类型里发生，不同肿瘤类型中tp53基因的突变频率不同，最高的是子宫癌肉瘤，肺腺癌居中也达到了60%多（见图3）。 TP53基因在约90%的小细胞肺癌（ SCLC ） …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …

The TP53 Database compiles various types of data and information from the literature and generalist databases on human TP53 gene variations related to cancer. The database is …

2023年3月1日 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …

TP53，是17号染色体的基因，该基因编码一种包含转录激活、DNA结合和寡聚结构域的抑癌蛋白。