Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα).

BC011是一款新型TNFR2非阻断治疗抗体，来源于 RenMab 人源化IgG小鼠。 通过在TNFR2人源化的肿瘤同源小鼠模型中进行无差别、高通量的体内有效性筛选，从大量候选抗体中筛选出了BC011。 BC011能够促进 CD8+T细胞 增殖，耗竭 Treg细胞，从而增加肿瘤微环境中效应T细胞的比例。 TNFR2靶点概览. TNFRSF1B （TNF receptor superfamily member 1b）为TNF受体超家族成员，也称为TNFR2，在某些免疫细胞亚群（如CD4+和CD8+ T细胞）、内皮细胞、小胶质 …

tnfr2在免疫细胞中主要表达在单核细胞， treg 等，通过tam，nk，treg等参与肿瘤免疫环境调节。目前关于tnfr2的靶向研究既有激动剂也有拮抗剂，主要取决于tnfr2在不同条件环境下所扮演的角色，一方面当tnfr2作为免疫抑制分子，拮抗剂可以降低tme这种免疫抑制作用 ...

Tumor necrosis factor (TNF) receptor-2 (TNFR2) affects tumor development and metastasis in several ways. TNFR2 promotes tumor immune escape by virtue of its ability to stimulate various immune suppressive cell types, e.g., regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) and can act as an oncogene.

TNFR2是肿瘤坏死因子受体超家族 (tumor necrosis factor receptor superfamily, TNFRSF)的成员之一，TNFR2通过与其配体肿瘤坏死因子（TNF）结合来调节免疫细胞的活化和功能。 当TNF与TNFR2结合会激活下游信号通路，从而促进细胞存活、增殖和分化，并参与炎症、免疫调节等生理和病理过程 [1]。 在肿瘤微环境中，TNFR2表达在抑制性免疫细胞中，包括调节性T细胞 (Tregs)和髓源抑制性细胞 (MDSCs)。 在急性髓细胞白血病、肺癌和卵巢癌等多种肿瘤中，异常升高 …

2021年10月11日 · 研究发现，tnfr2已成为肿瘤免疫逃逸、肿瘤生长以及检查点阻断抵抗性的潜在诱因。tnfr2在多类肿瘤中选择性表达为表面癌基因，具有促进肿瘤细胞增殖的功能。

Tumor necrosis factor (TNF) receptor 2 (TNFR2) is one of two receptors of the cytokines, TNF and lymphotoxin-α. TNFR1 is a strong inducer of proinflammatory activities. TNFR2 has proinflammatory effects too, but it also elicits strong anti-inflammatory activities and has protective effects on oligod …

There is compelling evidence that tumor necrosis factor (TNF) receptor type II (TNFR2) plays a decisive role in the activation and expansion of Tregs and other types of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs). Furthermore, TNFR2 is also expressed by some tumor cells.

2022年4月13日 · To provide a safer and more precise treatment approach for tumor immunotherapy, we need to explore the specific mechanism of TNFR2 in the tumor microenvironment and accurately understand the expression level of TNFR2 and the ratio of TNFR2 + T cells in various T cell subgroups.

TNFRSF1B（TNF receptor superfamily member 1b） 为TNF受体超家族成员, 也称为TNFR2，主要表达在肿瘤微环境中的 Treg细胞 和多种肿瘤细胞中（如卵巢癌和肠癌）。 其配体TNF主要识别TNFR1进行凋亡，依赖TNFR2进行与T细胞存活相关的功能——通过 NF-κB信号 促进 pro-survival基因 的 ...