Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] TNF is produced primarily by activated …

Tumor necrosis factor alpha (TNF-α) is a cytokine that has pleiotropic effects on various cell types. It has been identified as a major regulator of inflammatory responses and is known to …

Jun 2, 2022 · TNF inhibitors work by blocking the activity of a protein called TNFα. This protein normally helps with important functions such as fat metabolism and blood clotting, and excess …

Dec 19, 2023 · Tumor necrosis factor (TNF) is a type of protein that helps support your body's immune response. It is key to the inflammation process that supports healing when your body …

Tumor necrosis factor (TNF) is a critical cytokine, which contributes to both physiological and pathological processes. This mini-review will briefly touch the history of TNF discovery, its …

Tumor Necrosis Factor Alpha (TNF-α) is a cytokine that acts as an arbitrator of the local tissue environment following injury, and is involved in bone tissue regeneration. It can initiate …

Aug 1, 2000 · This article will review the structure/function relationships of the TNF alpha and the TNF receptor superfamily. It will also discuss insights as to how structural features play a role …

Mar 30, 2025 · This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It …

TNF-alfa inhibitors treat a wide range of inflammatory conditions such as rheumatoid arthritis (RA), psoriatic arthritis, juvenile arthritis, Crohn's disease, ulcerative colitis, ankylosing …

Tumor necrosis factor has direct, in vitro antitumor cytotoxicity on 30% to 50% of tumor cell lines, and it has been demonstrated to be active in vivo against both murine tumors and human …