The aim of the present study was to determine whether the tumor necrosis factor (TNF)-α mRNA expression level and rs1799964 polymorphism are the genetic susceptibility component of IBD …

2025年3月30日 · TNF (Tumor Necrosis Factor) is a Protein Coding gene. Diseases associated with TNF include Immunodeficiency 127 and Asthma. Among its related pathways are MIF …

2024年10月23日 · We observed that m6A modification of specific adenosines in the 3′UTR of TNF mRNA by WTAP and ZC3H13 promotes destabilization of TNF and thereby restricts TNF …

2017年9月25日 · In addition, we found that TNF-α mRNA was down-regulated by miR-181a-5p mimic, and significantly up-regulated by miR-181a-5p inhibitor. Taken together, we identified …

Notably, induction of TNF gene transcription after exposure to certain stimuli in specific cell types is paradigmatic of an immediate early gene. For example, after T and B cell activation or after …

Hepatic TNF-α mRNA expression increased early and transiently with a peak at 12 h, whereas sustained elevation of TNF-α gene expression was observed in kidneys and lungs. Especially …

2024年11月15日 · Ultimately, our investigation confirmed that cartilage-optimized adalimumab mRNA-LNP effectively inhibits the TNF-α-induced inflammation and ECM degradation in vitro …

2021年7月1日 · IL-1β and TNF-α are canonical immune response mediators that play key regulatory roles in a wide range of inflammatory responses to both chronic and acute …

2016年3月15日 · In this study, we detail a mechanism of posttranscriptional repression of TNF mRNA by GAPDH binding to the TNF 3' untranslated region. Using RNA immunoprecipitation, …

2017年9月19日 · We used quantitative real time-PCR to analyse mRNA expression levels of TNFSF ligands. Murine models of acute ischemic renal injury, chronic oxalate nephropathy, …