The role of TNF-α in rheumatoid arthritis: a focus on regulatory T ...
One of the main therapies involves Tumor Necrosis Factor alpha (TNF-α) inhibitors. In the RA immune-environment, TNF-α has been shown to have an influential and extensive but as yet …
TNF inhibitor therapy for rheumatoid arthritis - PMC
Immunotherapy has markedly improved treatment outcomes in rheumatoid arthritis (RA). Tumor necrosis factor (TNF)-α antagonists, such as infliximab (IFX), etanercept (ETN), adalimumab …
Are TNF inhibitors still the agent of choice for RA? - Nature
2023年10月12日 · Despite changes to the therapeutic landscape, TNF inhibitors look set to remain an important treatment option for the foreseeable future. Contemporary trainees in …
TNF and TNF receptors as therapeutic targets for rheumatic
2023年8月4日 · TNF has pleiotropic effects and can both promote and inhibit pro-inflammatory processes. The integrated net effect of TNF in vivo is a result of cytotoxic TNFR1 signalling …
The role of TNF-α in rheumatoid arthritis: a focus on ... - PubMed
2016年9月15日 · One of the main therapies involves Tumor Necrosis Factor alpha (TNF-α) inhibitors. In the RA immune-environment, TNF-α has been shown to have an influential and …
The many faces of TNF in arthritis - Nature
2020年9月1日 · Indeed, TNF inhibitors are highly efficacious in various autoimmune diseases, including rheumatoid arthritis (RA). “Despite its success, anti-TNF therapy works for less than …
Pathogenic role of TNFα in rheumatoid arthritis - ScienceDirect
2005年9月1日 · Tumour necrosis factor-alpha (TNFα) is central to pathogenesis of many inflammatory diseases including rheumatoid arthritis (RA). In patients with RA, TNFα is …
Role of tumor necrosis factor‐alpha in rheumatoid arthritis: a review ...
2007年12月5日 · Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a pivotal role in regulating the inflammatory response in rheumatoid arthritis (RA). Although it is …
Choosing the Right TNF Inhibitor Therapy for Rheumatoid Arthritis
2017年12月20日 · Most of the important differences among TNFis have been attributed to their structure. 3 The 5 TNFis approved for use in RA include 3 full monoclonal antibodies: …
TNF Inhibitor Drugs: Autoimmune Disease Treatments - WebMD
2022年12月6日 · What Is a TNF Inhibitor? TNF inhibitors are drugs that help stop inflammation. They're used to treat diseases like rheumatoid arthritis (RA), juvenile arthritis, psoriatic …