Transposons of the Tn 3 family form a widespread and remarkably homogeneous group of bacterial transposable elements in terms of transposition functions and an extremely versatile system for mediating gene reassortment and genomic plasticity owing …

The Tn3 transposon is a 4957 base pair mobile genetic element, found in prokaryotes. It encodes three proteins: β-lactamase, an enzyme that confers resistance to β-lactam antibiotics (and is encoded by the gene bla). Tn3 is an example of replicative …

2022年10月18日 · Tn3 is a widespread family and among the first identified bacterial transposons famed for their contribution to the dissemination of antibiotic resistance. Transposition within this family is...

Transposons of the Tn3 family form a widespread and remarkably homogeneous group of bacterial transposable elements in terms of transposition functions and an extremely versatile system for mediating gene reassortment and genomic plasticity owing …

2024年9月23日 · Tn3 family transposons are a widespread group of replicative transposons, notorious for contributing to the dissemination of antibiotic resistance, particularly the global prevalence of carbapenem resistance. The transposase (TnpA) of these elements catalyzes DNA breakage and rejoining reactions req …

The Tn3 Transposon Finder (Tn3_finder) performs the automatic prediction of transposable elements of the Tn3 family in bacteria and archaea. It compares user-provided bacterial and archaeal genome sequences to custom Tn 3 transposase and …

Our research has largely focused on the identification and functional characterization of Tn 3 family elements, which are the most abundant group of bacterial transposons. These elements are characterized by the presence of genes encoding large highly related transposases.

2024年8月9日 · Tn 3 family transposons are a widespread group of replicative transposons, notorious for contributing to the dissemination of antibiotic resistance, particularly the global prevalence of carbapenem resistance. The transposase (TnpA) of these elements catalyzes DNA breakage and rejoining reactions required for transposition.

2007年7月12日 · This chapter discusses the organization of Tn3-family transposons and their transposition (the formation and resolution of the cointegrate intermediate).

Tn3 is a widespread family and among the first identified bacterial transposons famed for their contribution to the dissemination of antibiotic resistance. Transposition within this family is mediated by a large TnpA transposase, which facilitates both transposition and target immunity.